年轻复发性卵巢内胚窦瘤多次复发的相关因素分析  

Analysis of related factors of multiple relapses for recurrent ovarian endodermal sinus tumor in young patients

作　　者：郭杨垄 朱笕青[1] 

机构地区：[1]浙江省肿瘤医院妇瘤外科,浙江杭州310022

出　　处：《中国现代医生》2016年第29期29-33,共5页China Modern Doctor

基　　金：浙江省自然科学基金(Y2100593)

摘　　要：目的 分析年轻复发性卵巢内胚窦瘤患者多次复发的相关因素。方法 对我院自2000年1月~2013年1月治疗的13例年轻复发性卵巢内胚窦瘤患者进行回顾性分析,通过影像学及血清学指标判断卵巢内胚窦瘤是否复发或多次复发,评价无疾病进展生存时间,再通过比较相关因素（年龄、初次手术术后残余肿瘤、FIGO分期、病理类型、初次复发前含铂化疗疗程数、初次复发后再次减瘤术、初次复发后含铂化疗疗程数）,找出年轻复发性卵巢内胚窦瘤患者多次复发的相关因素。结果 单因素分析中,年龄、初次手术术后残余肿瘤、FIGO分期、病理类型、初次复发前含铂化疗疗程数、初次复发后再次减瘤术并不是年轻复发性卵巢内胚窦瘤患者多次复发的相关因素,而初次复发后含铂化疗疗程数则极有可能是该部分患者多次复发的相关因素,且初次复发后含铂疗程数≥4的患者比初次复发后含铂疗程数〈4的患者更容易出现多次复发。在多因素分析中,均未能证实这些因素对年轻复发性卵巢内胚窦瘤患者多次复发的影响有统计学意义。结论 初次复发后含铂化疗疗程数有可能是年轻复发性卵巢内胚窦瘤患者多次复发的相关因素,但影响作用有限。Objective To analyze related factors of multiple relapses for recurrent ovarian endodermal sinus tumor in young patients. Methods A total of 13 young patients with recurrent ovarian endodermal sinus tumor who were treated in our hospital from January 2000 to January 2013 were retrospectively analyzed. Whether ovarian endodermal sinus tumor was recurrent or multiply recurrent was determined by imaging and serological indicators, and progression-free survival was evaluated. Then by comparing the relevant factors（age, residual tumor after initial operation, FIGO staging, pathological type, the number of platinum-based chemotherapy courses before initial relapse, number of tumor reduc- tion after initial recurrence, the number of platinum-based chemotherapy courses after initial recurrence）, relevant fac- tors of multiple relapses in the young patients with recurrent ovarian endodermal sinus tumor were found out. Results In univariate analysis, age, residual tumor after initial operation, FIGO staging, pathological type, the number of plat- inum-based chemotherapy courses before initial relapse, number of tumor reduction after initial recurrence were not relevant factors of multiple relapses in the young patients with recurrent ovarian endodermal sinus tumor. The number of courses of platinum-based chemotherapy regimens after the initial relapse was most likely to be the relevant factor for multiple relapses in these patients. The patients with the number of platinum-based chemotherapy courses ≥4 after initial relapse was more likely to show multiple relapses than the patients with the number of platinum-based chemotherapy courses 〈g after the initial relapse. In the multivariate analysis, the effects of these factors on multiple relapses in young patients with recurrent ovarian endodermal sinus tumor were not confirmed to have statistical signifi- cance. Conclusion The number of platinum-based chemotherapy courses after initial relapse may be the relevant factor for multiple relapses in young patients with r

关 键 词：卵巢内胚窦瘤 多次复发 铂类 化疗 无疾病进展生存时间 

分 类 号：R737.31[医药卫生—肿瘤]