糜蛋白酶C在胰腺炎和胰腺癌发生发展中的作用  

Role of chymotrypsin C in development and progression of pancreatitis and pancreatic cancer

作　　者：刘泽杰[1] 宋沂林 李红[1] 冯英明[1] 苏海川[1] 

机构地区：[1]第四军医大学附属唐都医院肿瘤科,西安710038

出　　处：《临床肝胆病杂志》2016年第11期2222-2225,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(3157080036)

摘　　要：糜蛋白酶C(CTRC)是由胰腺腺泡细胞合成,胰腺导管细胞分泌的蛋白酶原,属于丝氨酸糜蛋白酶家族。其主要作用是调控胰蛋白酶的活化与降解的平衡,维持胰腺组织结构和功能的完整性。CTRC基因位点突变,使得胰蛋白酶原的活化及胰蛋白酶的降解异常,导致慢性胰腺炎的发生。CTRC表达下调甚至缺失可能与胰腺癌的发生及转移有关。介绍了CTRC基因的结构、生物学功能,及其在胰腺炎、胰腺癌发生发展中的作用机制。Chymotrypsin C（ CTRC） is a trypsinogen synthesized by pancreatic acinar cells and secreted by pancreatic duct cells and belongs to the family of serine chymotrypsin. The main function of CTRC is to regulate the balance between activation and degradation of trypsin and maintain the structural and functional integrity of the pancreas. CTRC gene mutations can cause abnormal activation of trypsinogen and abnormal degradation of trypsin and then lead to the development of pancreatitis. The downregulation or absence of CTRC expression may be associated with the development and metastasis of pancreatic cancer. This article introduces the structure and biological function of CTRC and its mechanism of action in the development and progression of pancreatitis and pancreatic cancer.

关 键 词：糜蛋白酶 胰腺炎 胰腺肿瘤 综述 

分 类 号：R576[医药卫生—消化系统]