NF-κB和eIF4E在子宫内膜上皮内瘤变和子宫内膜样癌中的表达及意义  

Expression and significance of NF-κB and eIF4E in endometrial intraepithelial neoplasia and endometrioid carcinoma

作　　者：赵庆庆[1] 宋文静[1] 

机构地区：[1]天津医科大学病理学教研室,天津300070

出　　处：《天津医科大学学报》2016年第6期483-486,共4页Journal of Tianjin Medical University

摘　　要：目的:探讨核转录因子-κB(NF-κB)和eIF4E在子宫内膜上皮内瘤变(EIN)和子宫内膜样癌(EC)中的表达规律及意义。方法:免疫组织化学SP法检测NF-κB和eIF4E在增殖期子宫内膜、子宫内膜增生、EIN及EC中的表达,应用Mann-Whitney U检验及Wilcoxon检验进行数据统计分析。结果:(1)NF-κB在4组中呈递增性表达,EIN组与EC组间无显著差异性(P>0.05),与其余两组组间表达均有统计学意义(P<0.05)。(2)eIF4E在EC中的表达明显高于增殖期子宫内膜、子宫内膜增生及EIN,且EIN组与各组间差异有统计学意义(P<0.05)。(3)NF-κB和eIF4E在EIN及相关病变中的表达有显著相关性(r=0.949,P<0.05)。结论:NF-κB和e IF4E在EIN及EC中高表达,在EIN发展为EC的过程中逐渐被激活,进而加速转录、翻译,增大EIN进展为子宫内膜样癌的可能性。Objective： To investigate the expressions and roles of NF-κB and eIF4E in the endometrial intraepithelial neoplasia（EIN） and endometrioid carcinoma（EC）. Methods：Immunohistochemical SP method was used to detect the expressions of NF-κB and eIF4E in the proliferative stage of endometrium, hyperplasia endometrium, EIN and EC. The statistical data using test were analyzed MannWhitney U test and Wilcoxon. Results： （1） The expression levels of NF-κB increased gradually, and there was no statistically significant difference between EIN and EC（P〉0.05）. However, difference between the EIN and other groups was significance.（2）The positive rate of eIF4E was significantly higher in EC than in proliferative stage of endometrium,hyperplasia endometrium and EIN（P 〈 0.05）.（3）NF-κB and eIF4E had a strong correlation between EIN and associated lesions（r = - 0.949,P〈0.05）. Conclusion： NF-κB and eIF4E are highly expressed in EIN and EC. They may be gradually activated in the process of EIN development to EC, and then accelerate transcription or translation,and increase the possibility of endometrial carcinoma.

关 键 词：子宫内膜上皮内瘤变 子宫内膜样癌 NF-ΚB EIF4E 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]