急性闭角型青光眼急性发作早期的视网膜神经纤维层厚度变化特征分析  

Characteristics analysis of retinal nerve fiber layer thickness change of acute angle closure glaucoma in early acute episodes

作　　者：贺新征[1,2] 陶黎明[1] 李岩[2] 王静[1] 李军[2] 简春燕[2] 

机构地区：[1]安徽医科大学第二附属医院眼科,安徽省合肥市230601 [2]解放军第113医院眼科,浙江省宁波市315040

出　　处：《眼科新进展》2016年第12期1150-1152,1156,共4页Recent Advances in Ophthalmology

基　　金：安徽省教育厅重点项目(编号:KJ2016A340)~~

摘　　要：目的观察急性闭角型青光眼急性发作早期视网膜神经纤维层厚度的变化特点。方法收集急性闭角型青光眼单次急性发作患者45例,在病程2周内采用光学相干断层扫描(optical coherence tomography,OCT)测量双眼视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度,将发作眼与对侧眼的数据进行比较,并分析RNFL厚度与治疗前眼压、高眼压持续时间和年龄的相关性。结果急性发作眼RNFL厚度为(118.80±38.45)μm,上方、下方、鼻侧、颞侧分别为(148.67±58.59)μm、(159.80±57.82)μm、(89.60±31.37)μm、(79.47±27.54)μm;对侧眼RNFL厚度为(98.20±16.89)μm,上方、下方、鼻侧、颞侧分别为(120.13±23.61)μm、(131.60±27.41)μm、(74.01±18.07)μm、(67.80±13.41)μm。急性发作眼比对侧眼的RNFL厚度增加,且发作眼上方、下方、鼻侧和颞侧各个象限的RNFL较对侧眼均增厚,差异均有统计学意义(均为P<0.05)。急性发作眼的RNFL厚度与治疗前眼压呈正相关(r=0.370,P<0.05),与高眼压持续时间呈正相关(r=0.603,P<0.01);与年龄无关(r=-0.317,P>0.05)。结论急性闭角型青光眼单次急性发作后,RNFL明显水肿,这种变化可持续到发作后2周,且治疗前眼压越高、高眼压持续时间越长,RNFL水肿越严重。Objective To observe characteristics of retinal nerve fiber layer （RNFL） thickness change in early acute episodes of acute angle closure glaucoma. Methods Forty-five patients with single acute episode of acute angle closure glauco- ma were collected,and RNFL thickness was measured by optical coherence tomography （OCT） imaging within 2 weeks after acute attack. The data of the attacked eyes were compared with the fellow eyes. The correlation of RNFL thickness with intraocular pres- sure before treatment,intraocular pressure duration and age were analyzed. Results The average RNFL thickness of the attacked eye was （ 118.80 ± 38.45 ） μm, superior was （ 148.67±58.59） μm,inferior was （ 159.80 ±57.82） μm,nasal was （89.60 ± 31.37）μm, and temporal was （ 79.47 ± 27.54 ） μm. The average RNFL thickness of the fellow eye was （98.20 ± 16.89） μm, superior was （ 120. 13 ± 23.61 ）μm, inferior was （ 131.60 ± 27.41 ）μm,nasal was （74.00 ± 18.07 ）μm, and temporal was （ 67.8 ±13.41 ） μm. Aver- age RNFL and RNFL of each quadrant （ superior,inferior,nasal and temporal） of the at- tacked eyes were thicker than those of the fellow eyes, and all these differences were statistically signifieant （ all P 〈0.05 ）. The average RNFL thickness of the attacked eyes was positively correlated with intraocular pressure before treatment （ r = 0. 370, P 〈 0. 05 ） and it was also positively correlated with high intraocular pressure duration （ r = 0.603 ,P 〈 0.01 ）. However, it was not correlated with age （ r = 0.317, P 〉 0.05 ）. Conclusion After a single acute attack of acute angle closure glaucoma, RNFL edema is obvious, which can last 2 weeks. In addition, the degree of RNFL edema is aggravated by higher intraocular pressure before treatment and longer duration of high intraocular

关 键 词：视网膜神经纤维层 急性闭角型青光眼 光学相干断层扫描 

分 类 号：R775[医药卫生—眼科]