MicroRNAs在视网膜病变中作用的研究进展  

Research progress on roles of microRNAs in retinopathy

作　　者：彭云[1] 叶琳 

机构地区：[1]深圳市眼科医院深圳市眼科学重点实验室暨南大学医学院深圳眼科中心,广东省深圳市518040

出　　处：《眼科新进展》2016年第12期1192-1195,共4页Recent Advances in Ophthalmology

基　　金：深圳市科技技术项目(编号:JCYJ20140415174819504)~~

摘　　要：微小RNA(microRNAs,miRNAs)是近年来发现的普遍存在于生物基因组的非编码蛋白质的单链小RNA,长约22个核苷酸,它们通过在转录后和翻译水平调节基因表达而调控生理和病理过程。视网膜病变是眼科难治性疾病和致盲的重要原因。最新研究表明,MicroRNAs在视网膜病变的发生发展中起到十分重要的调控作用。MicroRNAs用于治疗视网膜病变具有广阔的前景。本文就MicroRNAs的功能及其在视网膜病变中的研究现状进行综述。MicroRNAs （miRNAs）, about 22 nt in length, are small single-strand RNA discovered in recent years that universally exist in the genome of creatures. They control physiological and pathological processes through regulation of gene expression at either post-transcriptional or translational level. Retinopathy is one of the most im- portant clinical problems in ophthalmology and cause of blindness. Recent studies have demonstrated that miRNA play a crucial role in the development of retinopathy. The use of miRNAs provides novel therapeutic approaches for retinopathy. This article reviews the research progress on he functions and expressions of miRNA in retinopathy.

关 键 词：微小核糖核酸 视网膜病变 治疗手段 

分 类 号：R774.1[医药卫生—眼科]