圣·约翰草对高同型半胱氨酸血症患者卒中后抑郁预防作用初步观察  

Preliminary observation of St. John grass' preventive effect on post-stroke depression patients with hyperhomocysteinemia

作　　者：刘喜艳[1] 甄微[1] 刘东辉[1] 李会敏[1] 

机构地区：[1]河北大学附属医院神经内科,河北071000

出　　处：《脑与神经疾病杂志》2016年第12期759-762,共4页Journal of Brain and Nervous Diseases

基　　金：河北大学研究生创新资助项目(X2015091)

摘　　要：目的本研究对伴高同型半胱氨酸血症(HHcy)的急性脑卒中患者早期采用圣·约翰草进行卒中后抑郁(PSD)的预防性治疗,观察PSD发病率。方法收集急性脑卒中患者,且空腹血浆同型半胱氨酸(Hcy)>20μmol·L^(-1)共80例分为两组,均给予常规治疗,两组均加服叶酸+甲钴铵,治疗组在对照组的基础上加服圣·约翰草提取物片600mg·d^(-1),于治疗前及治疗后6、12w采用汉密尔顿抑郁量表评分,并比较12w后两组间PSD的发病率差异,评价预防性治疗疗效。结果治疗12w后,治疗组PSD的总发病率(7.89%)明显低于对照组(25.64%),两者间差异有统计学意义(Z=2.057,P=0.040)。结论针对伴有高同型半胱氨酸血症的急性脑卒中患者给予叶酸、甲钴胺及抗抑郁剂的预防性治疗有效。Objective To study on with hyperhomocysteinemia of acute cerebral stroke patients with early use St John＇s wort to improve the preventive treatment of post-stroke depression（PSD）. Method Continuous collection acute cerebral stroke patients and fasting plasma homocysteine（Hcy）20μmol·L^（-1）, a total of 80 cases were divided into two groups, both given conventional therapy,and each group plus folate and methylcobalamin, the treatment group take St John＇s wort 600 mg everyday on the basis of the control group.Before treatment and after 6 and 12 weeks by Hamilton depression rating scale, and compared the PSD incidence of differences between the two groups after 12 weeks, evaluating the effect of prophylactic treatment. Results After 12 weeks of treatment, the treatment group with depression incidence rate（7.89%） was significantly lower than the control group（25.64%）, the differences statistically significant（Z=2.057,P=0.040）. Conclusion For associated with high homocysteine in acute stroke patients given prophylactic folate plus methylcobalamin and antidepressant treatment is effective.

关 键 词：高同型半胱氨酸血症 卒中后抑郁 预防 

分 类 号：R743.32[医药卫生—神经病学与精神病学]