维生素D联合左旋多巴降低血管性帕金森综合征跌倒风险  

The combination of vitamin D and L-dopa reduces the risk of falls in vascular Parkinsonism

作　　者：缑元冲[1] 牛晓波[1] 段贺春 张晓阳[1] 李晓楠[1] 

机构地区：[1]安阳市灯塔医院神经内科,河南455000

出　　处：《脑与神经疾病杂志》2016年第12期774-777,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨维生素D联合左旋多巴是否降低血管性帕金森综合征(VP)跌倒风险。方法 48例VP患者分为维生素D组、对照组各24例。所有患者均给予左旋多巴治疗,维生素D组同时补充1000 IU·d^(-1)维生素D_2,而对照组不补充维生素D_2。比较两组治疗后2年内跌倒发生次数。结果维生素D组下肢肌力明显提高。2年内两组中每个观察对象跌倒次数差异有统计学意义(对照组1.5±0.4较维生素D组0.6±0.3,P<0.05)。在2年观察期间,对照组23例患者中有3例发生髋部骨折,而维生素D组23例患者中有1例发生髋部骨折。结论维生素D联合左旋多巴可以降低血管性帕金森综合征跌倒风险。Objective To determine wether the combination of vitamin D and L-dopa reduces the risk of falls in vascular Parkinsonism（VP）.（MCAO） in rats. Method Forty-eight patients with VP were divided into vitamin D group（24 cases） and control group（24 cases）. All patients were treated with L-dopa, the patients in the vitamin D group received 1000 IU ergocalciferol daily, but control group did not received. The number of falls were compared between the two groups during following 2 years. Results Improved muscle strength of lower extremities was observed in the vitamin D group. There was significant difference between the two groups in the number of falls per subject during the 2 years（1.5±0.4 in the control group and 0.6±0.3 in the vitamin D group, P〈0.05）. Hip fractures occurred in 3 of 23 in the control group and one of 23 in the vitamin D group during the 2-year study period. Conclusion These results suggest that the combination of vitamin D and L-dopa decreases falls in VP.

关 键 词：血管性帕金森综合征 跌倒 左旋多巴 维生素D 

分 类 号：R741.05[医药卫生—神经病学与精神病学]