FOXQ1和CyclinD1在胃癌中的表达及其临床意义  

Expression of FOXQ1 and CyclinD1 in gastric carcinoma and its clinical significance

作　　者：陈丽丽[1] 曹学全[1] 卢洪胜[1] 杨朝晖[1] 范广民[1] 章辉[1] 顾华敏[1] 

机构地区：[1]台州市中心医院病理科,318000

出　　处：《浙江医学》2016年第22期1819-1821,共3页Zhejiang Medical Journal

摘　　要：目的研究叉头框蛋白Q 1(FOXQ1)和细胞周期蛋白D1(CyclinD1)在胃癌中的表达及其临床意义。方法应用免疫组化En Vision法检测80例胃癌组织和25例癌旁组织中FOXQ1和Cyclin D1的表达情况,分析其与胃癌临床病理特征的关系。结果胃癌组织中FOXQ1和Cyclin D1阳性表达率均高于癌旁组织(均P<0.05);在不同肿瘤浸润深度、有无淋巴结转移及不同临床分期者之间的差异均有统计学意义(均P<0.05),而在不同年龄、性别、肿瘤大小及分化程度者之间的差异均无统计学意义(均P>0.05)。胃癌组织中FOXQ1阳性表达率与Cyc lin D1阳性表达率呈正相关(P<0.05)。结论 FOXQ1和Cyc lin D1高表达在胃癌的发生、发展中起作用,联合检测FOXQ1和Cyclin D1可用于判断胃癌的浸润、转移潜能及患者的预后。Objective To investigate the expression and clinical significance of FOXQl and CyclinDl in gastric carcinoma.Methods The expression of FOXQl and CyclinDl in 80 samples of gastric carcinoma and 25 samples of pericancerous tissue was detected by immunohitochemical EnVision method,and its relationship with clinical pathological features was analyzed.Results The positive expression rates of FOXQl and CyclinDl in gastric carcinoma tissues were significantly higher than those in corresponding percicancerous gastric mucosa（both P〈0.05）.The positive expression rates of FOXQl and CyclinDl were correlated with the depth of tumor invasion,lymph node metastasis and clinical stage（both P〈0.05）,but not correlated with age,sex,tumor size ordegree of differentiation（P 〉0.05）.The expression ofFOXQl in gastric carcinoma was positively correlated with the expression of CyclinDl（P〈0.05）.Conclusion The high expression of FOXQl and CyclinDl may be involved in the occurrence and development of gastric cancer,the combined detection of FOXQl and CyclinDl can be used to determine the invasive and metastatic potential of gastric carcinoma and the prognosis of the patients.

关 键 词：胃癌 FOXQ1 CYCLIND1 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]