三维适形放射治疗联合替吉奥治疗局部晚期非小细胞肺癌的疗效观察  

Three dimensional conformal radiotherapy combined with S-1 in the treatment of locally advanced non-small cell lung cancer

作　　者：李凤玉[1] 王舒琦[1] 王丽梅[2] 

机构地区：[1]解放军第251医院肿瘤二科,河北张家口075000 [2]通辽市医院肿瘤放疗科,内蒙古通辽028000

出　　处：《中国医学装备》2016年第11期70-73,共4页China Medical Equipment

基　　金：河北省科技支撑计划(09276157)"肺功能与放射性肺损伤的相关性研究"

摘　　要：目的:探讨三维适形放射治疗(3D-CRT)联合替吉奥(S-1)治疗局部晚期非小细胞肺癌的疗效及安全性。方法:选取80例局部晚期非小细胞肺癌患者,按照随机数表法将其分为观察组和对照组,每组40例。观察组采用3D-CRT联合替吉奥治疗,3D-CRT治疗总剂量为60 Gy(2.0 Gy/次,5次/周,治疗6周);自放射治疗开始同时口服替吉奥胶囊80 mg/(m^2·d),2次/d,服药两周停1周,3周为1个周期,共口服3个周期。对照组采用单纯3D-CRT治疗。结果:观察组总有效率为85.0%,临床受益率为87.5%,明显高于对照组,两组相比有差异(x^2=38.958,P<0.05)。两组治疗后不良反应主要为放射性食管炎所致的吞咽疼痛、恶心、食欲不振以及白细胞下降,不良反应主要为Ⅰ~Ⅱ级,观察组与对照组比较无差异(x^2=1.27,x^2=1.05,x^2=0.13;P>0.05)。结论:3D-CRT联合替吉奥治疗局部晚期非小细胞肺癌是一种安全有效的治疗方法,值得临床推广。Objective： To observe the effect of three dimensional conformal radiotherapy（3D-CRT） combined with S-1 and adverse reaction in the treatment of locally advanced nonsmall cell lung cancer effect. Methods： 80 patients with locally advanced non-small cell lung cancer were randomly divided into the observation group and the control group, each with 40 cases. The observation group adopted 3D-CRT with total dose of 60Gy（2Gy/time, 5 times/week, 6 weeks）. Since the beginning of radiotherapy, the patients in observation group took S-1 capsule 80 mg/（m^2·d） for 2 times a day, two weeks of oral stop for a week for a period, a total of 3 oral cycle. The control group was treated with simple 3D-CRT. Results： 2 months after the end of the recent curative effect, the total effective rate（Cr＋partial remission） and clinical benefit rate（Cr＋ partial response ＋ minor relief） were 85% and 87.5% in the observation group, higher than the control group. The major adverse reactions were radioactive esophagitis induced pain in swallowing, nausea, lack of appetite and the decrease of white blood cells, and the majority was I and II. There was no significant difference between the two groups（x^2=1.27, x^2=1.05, x^2=0.13; P〈0.05）. Conclusion： 3D-CRT combined with S-1 in the treatment of locally advanced non-small cell lung cancer is a safe and effective treatment method, is worth popularizing in clinical.

关 键 词：非小细胞肺癌 放射治疗 三维适形 替吉奥 

分 类 号：R734.2[医药卫生—肿瘤]