ABCG2在肾细胞癌临床随访中的意义  

Role of ABCG2 as a potentially prognostic factor during the follow-up of renal cell carcinoma

作　　者：马稔翌 罗方秀[1] 赵菊平[2] 何竑超[2] 王浩飞[2] 黄欣[2] 孙福康[2] 徐兆平[2] 周文龙[2] 祝宇[2] 沈周俊[2] MA Renyi LUO Fangxiu ZHAO Juping HE Hongchao WANG Haofei HUANG Xin SUN Fukang XU Zhaoping ZHOU Wenlong ZHU Yu SHEN Zhoujun(a Department of Pathology, Ruijin North Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201800, China Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine)

机构地区：[1]上海交通大学医学院附属瑞金医院北院病理科,上海200025 [2]上海交通大学医学院附属瑞金医院泌尿外科

出　　处：《临床泌尿外科杂志》2016年第11期986-990,共5页Journal of Clinical Urology

摘　　要：目的：探讨三磷酸腺苷结合转运蛋白G超家族成员2（ATP-Binding cassette transporter group 2,ABCG2）在肾细胞癌（RCC）临床随访中的意义。方法：从本院肾癌数据库中选择具有完整资料的RCC组织标本110例,患者年龄（56±10）岁（17-80岁）,随访时间为（72±30）个月（6-102个月）。以10例肾积水失功能的无癌肾组织为对照。使用ABCG2标准试剂盒对所有组织标本进行免疫组织化学染色,并结合临床、病理参数进行回归分析。结果：在110例RCC组织中,62例（56.4%）ABCG2呈阳性表达;在10例非肾癌组织中,ABCG2均呈阴性表达（P〈0.01）。RCC组织中ABCG2的表达水平与远处转移和5年存活率密切相关（P〈0.05）。RCC患者5年总生存率为79.1%,其中ABCG2阴性者为93.8%,ABCG2阳性者为67.7%（P〈0.001）,两组总生存时间分别为（85.1±22.7）个月和（62.1±32.8）个月（P〈0.001）。Cox多因素回归分析显示ABCG2是总生存时间的独立预后因子,相对危险度（risk ratio,RR）为2.846（P〈0.01）。结论：ABCG2的表达水平与RCC患者是否有远处转移及5年生存率密切相关,且ABCG2表达越强,RCC患者的预后越差。ABCG2是RCC的独立预后指标,推荐其可作为临床常规随访项目之一。Objective：To explore the role of ATP-binding cassette transporter group 2（ABCG2）as a potentially prognostic factor in the follow-up of renal cell carcinoma（RCC）.Method：We reviewed the RCC database in Ruijin hospital retrospectively and 110 cases of RCC confirmed as clear cell carcinoma in histology were enrolled.Patients＇ mean age was（56±10）（range,17-80）years old,and mean follow-up period was（72±30）（range,6-102）months.Another 10 cases of non-tumor nephrectomy due to hydronephrosis were elected as control group.Immunohistochemical staining standard procedure was used to detect the expressions of ABCG2.The association between ABCG2 expression and clinicopathological factors was analyzed by Cox regression method.Result：The rate of ABCG2 positive expression in 110 samples of sporadic RCC was 56.4% and other 10 hydronephrosis samples was 0,respectively（P〈0.01）.ABCG2 expression in RCC was significantly associated with metastasis and 5-year overall survival（OS）,（P〈0.05）.The rate of 5-year survival was 79.1%in 110 RCC patients.The rate of 5-year survival was 93.8%in the ABCG2（-）group and 67.7%in the ABCG2（＋-＋＋）group respectively（P〈0.001）.The OS in the ABCG2（-）group and ABCG2（＋-＋＋）group was（85.1±22.7）months and（62.1±32.8）months respectively（P〈0.001）.ABCG2 was considered as an independent prognostic factor for OS based on the Cox regression analysis（RR=2.846,P〈0.01）.Conclusions：ABCG2 expression is significantly associated with metastasis and OS among patients with clear cell RCC.The stronger ABCG2 expression is,the worse prognosis the patients will face.ABCG2 can be considered as a reliable independent prognostic factor in clear cell RCC and recommended as a clinical routine parameter during follow-up.

关 键 词：肾细胞癌 生物标志物 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]