肾细胞癌相关单核苷酸多态性的研究进展  

Research progress of renal cell carcinoma related single nucleotide polymorphisms

作　　者：雷小康[1] 宋一萌[1] 马潞林[1] LEI Xiaokang SONG Yimeng MA Lulin(Department of Urology, Third Hospital of Peking University, Beijing, 100191, China)

机构地区：[1]北京大学第三医院泌尿外科,北京100191

出　　处：《临床泌尿外科杂志》2016年第11期1040-1045,共6页Journal of Clinical Urology

摘　　要：肾细胞癌(RCC)是临床上最常见的泌尿系统恶性肿瘤之一。大量研究表明,遗传因素在RCC的发病中起重要作用。单核苷酸多态性作为第三代遗传标记,在有关RCC遗传易感性的研究方面受到了关注。通过对RCC相关单核苷酸多态性进行深入研究,有利于对RCC更好地采取预防、诊断和治疗措施。本文针对近些年与RCC相关单核苷酸多态性的研究进展作一综述。Renal cell carcinoma is one of the most common urological malignancies clinically.A large number of studies have shown that the genetic factor plays an important role in renal cell carcinoma pathogenesis.As the third generation of genetic marker,single nucleotide polymorphism has been paid attention to in renal cell carcinoma of the genetic susceptibility research.Therefore,the further research into the single nucleotide polymorphism will be highly beneficial to the prevention,diagnosis and treatment of renal cell carcinoma.This paper reviewed the recent research progress of renal cell carcinoma related single nucleotide polymorphisms.

关 键 词：肾细胞癌 单核苷酸多态性 遗传易感性 

分 类 号：R737.11[医药卫生—肿瘤]