表观遗传学与肿瘤及其临床应用  

Epigenetics of tumor and its clinical application

作　　者：冯敏[1] 曾景棠 谭艺清 饶绍奇[1] Feng Min Zeng Jingtang Tan Yiqing Rao Shaoqi(Institute for Medical Systerns Biology, Department of Medical Statisticsand Epidemiology, School of PublicHealth, Guangdong Medical College, Dongguan 523808, Chin)

机构地区：[1]广东医学院公共卫生学院流行病与卫生统计系医学系统生物学研究所,东莞523808

出　　处：《国际遗传学杂志》2016年第5期264-268,共5页International Journal of Genetics

基　　金：国家自然科学基金（31071166、81373085）;广东省科技计划攻关项目（2009A030301004）;东莞市重点科技项目（201108101015）;广东医学院基金（XGl001、JBl214、XZll05、STIF201122）

摘　　要：表观遗传学是指细胞表型中不涉及遗传物质核苷酸序列的改变所产生的可遗传改变，主要是指DNA甲基化、组蛋白乙酰化修饰及microRNA调控等机制。现研究表明表观遗传学改变在肿瘤发生发展中意义重大，近几年来，有关表观遗传学调控在抗肿瘤的临床应用也越来越多，并且一些表观遗传药物也已用于临床。本文将从表观遗传学与肿瘤的关系及其临床应用展开综述。The epigenetics mainly refers to the genetic alteration that is independent of DNA se- quence, such as DNA methylation, histone acetylation and microRNA regulation. Some studies have found that in the progress of tumorigenesis, epigenetics playes significant roles. In recent years, epigenetic regu- lation is increasingly used in the clinical application of anti-tumor, and some epigenetic drugs also have been used in clinical treatment. This article reviews the mechanisms underlying epigenetics, its roles in tumor initiation and clinical applications in tumor therapies.

关 键 词：表观遗传学 肿瘤 临床应用 

分 类 号：R73-3[医药卫生—肿瘤]