氨磷汀配合奈达铂同步放化疗局部晚期鼻咽癌的临床分析  

The Clinical Effect of Amifostine with Concurrent Chemotherapy Nedaplatin Locally Advanced Nasopharyngeal Carcinoma

作　　者：李素芳[1] 唐爽[1] 钟声学[1] 袁晓佳[1] 

机构地区：[1]广西科技大学第二附属医院放疗科,广西柳州545005

出　　处：《世界复合医学》2016年第2期29-34,共6页World Journal of Complex Medicine

基　　金：广西卫生厅自筹经费科研课题项目编号(合同号Z2013146)

摘　　要：目的研究观察氨磷汀配合奈达铂同步放化疗局部晚期鼻咽癌的临床效果。方法从该院2013年6月—2015年5月间收治的局部晚期鼻咽癌患者中选取82例进行分组研究,对照组给予奈达铂＋调强适型放疗治疗局部晚期鼻咽癌,观察组在对照组基础上加用氨磷汀配合治疗,观察两组间近期疗效、毒副作用的发生及其他不良反应等比较。结果对照组近期临床疗效中有效率为97.56%、观察组为95.12%,两组差异无统计学意义（P〉0.05）;随访1年内两组患者近期疗效,比较两组局部控制率均在87.8%-95.12%之间,远处转移均在2.44%-7.32%之间,两组差异无统计学意义（P〉0.05）;毒副作用比较中骨髓抑制、黏膜炎、口干燥症3项对照组比观察组的发生程度更高,而肝脏、肾脏毒性则两组程度相当,故骨髓抑制、黏膜炎、口干燥症中差异有统计学意义（P〈0.05）,而肝脏和肾脏毒性中差异无统计学意义（P〉0.05）;在3级或3级以上黏膜炎发生率中对照组明显比观察组多,平均持续时间长,两组组间差异有统计学意义（P〈0.05）;观察组中患者的白细胞、血红蛋白和血小板降低率中均比对照组少,两组组间差异具有统计学意义（P〈0.05）。结论氨磷汀配合奈达铂同步放化疗局部晚期鼻咽癌具有减低相关毒副作用对人体正常细胞起到防护的作用,具有临床实用推广的价值。Objective To study the observation of ammonia phosphorus nida, cooperate with platinum chemoradiation clinical effect of lo-cally advanced nasopharyngeal carcinoma. Methods From June 2013 to May 2015 were select 82 cases of patients with locally ad-vanced nasopharyngeal carcinoma group, control group given nida＇s platinum intensity-modulated optimal type of radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma, observation group in the control group on the basis of the total phosphorus ammonia with statins treatment, observing the recent curative effect between the two groups, the occurrence of side effects and other adverse reactions. Results Effective rate was 97.56% in control group recently clinical curative effect, the observation group was95.12%, no obvious difference in the two groups have no statistical significance（P〈0.05）;Within 1 year follow-up of two groups of patients in the near future curative effect, compare the two way local control rates were between 87.8% and 95.12%, distant metastasis were between 2.44% and 7.32%, no obvious difference in the two groups has no statistical significance（P〈0.05）;Side effects compared in bone marrow inhibition, mucositis, dry mouth disease occurred more than observation, three control group while the liver, kidney toxicity level in both groups, therefore, bone marrow suppression, mucositis, dry mouth disease in significant difference statistically significant（P〈0.05）, while no statistically significant difference in liver and kidney toxicity（P〈0.05）;At level 3 or level 3 above incidence of mucous membrane inflammation in the control group more clearly than observation group, the average duration of long, statistically significant difference between the two way（P〈0.05）. Patients in observation group of white blood cells, hemoglobin and platelet reduce rate of less than the control group, the differences between the two way statistically significant（P〈0.05）. Conclusions Phosphorus ammonia with statins nida�

关 键 词：氨磷汀 奈达铂 晚期鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]