紫杉烷类药物与葸环类药物用药顺序对乳腺癌患者近期疗效影响研究  

Influence of the medication administration sequence of taxanes and anthracyclines on the recent effect in patients with breast cancer

作　　者：黄六一[1] 

机构地区：[1]江苏省新沂市铁路医院外一科,221400

出　　处：《中国实用医刊》2016年第21期56-58,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨紫杉烷类药物与蒽环类药物用药顺序对乳腺癌患者近期疗效的影响，旨在为改善乳腺癌患者预后提供参考依据。方法选择2010年6月至2013年6月收治的60例乳腺癌患者作为研究对象，根据不同用药顺序分为观察组和对照组，每组30例，观察组第1天用多西他赛，第2天用表柔比星；对照组第1天用表柔比星，第2天用多西他赛。比较两组患者的临床疗效、不良反应及近期生存率。结果观察组总有效率、临床获益率分别为76．67％和93．33％，与对照组比较差异均未见统计学意义（P〉0．05）；观察组1、2年生存率分别为93．33％和86．67％，与对照组比较差异均未见统计学意义（P〉0．05）；两组患者不良反应发生率比较差异未见统计学意义（P〉0．05）。结论在乳腺癌新辅助治疗中，紫杉烷类药物与蒽环类药物用药顺序对患者的临床疗效及近期生存情况并无明显差异。Objective To observe the influence of the medication administration sequence of taxanes and anthracyclines on the recent effect in patients with breast cancer, in order to improve the prognosis of patients with breast cancer. Methods From June 2010 to June 2013, 60 patients with breast cancer were selected as the research object according to the medication administration sequence, they were divided into observation group and control group, with 30 cases in each group. The observation group was treated with docetaxel on the first day and epirubicin on the second day; the control group was treated with epirubicin on the first day, and docetaxel on the second day. The clinical efficacy, adverse reactions and short-term survival rates were compared between the two groups. Results The total effec- tive rate and clinical benefit rate of the observation group were 76.67% and 93.33% , there were no sig- nificant difference between the two groups （P 〉 0.05 ）. The 1, 2 year survival rate in observation group was 93.33% and 86.67% , there were no significant difference between the two groups （P 〉 0. 05 ）. There was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0. 05 ）. Conclusions In the neoadjuvant treatment of breast cancer, there were not significantly differ- ence between taxanes and anthracyclines drugs in sequence on the patient＇ s clinical curative effect and short-term survival.

关 键 词：乳腺癌 紫杉烷类药物 蒽环类药物 用药顺序 近期疗效 

分 类 号：R737.9[医药卫生—肿瘤]