透明质酸合酶与肿瘤  

The effects of Hyaluronan synthase on tumors

作　　者：关琳[1] 苗鹏[2] 黄玉红[1] 孙明军[1] 

机构地区：[1]中国医科大学附属第一医院消化内科,辽宁沈阳110001 [2]中国医科大学附属第一医院肛肠外科,辽宁沈阳110001

出　　处：《解剖科学进展》2016年第6期662-666,共5页Progress of Anatomical Sciences

基　　金：辽宁省科技计划项目(2009225022)

摘　　要：透明质酸合酶(HAS)是分布于质膜上的一种能够特异性作用于透明质酸(HA)合成过程中的双功能糖基转移酶,它可能通过抑制凋亡、促进细胞粘附及上皮间质转换(EMT)、增加O-GlcNAc糖基化修饰等机制参与大肠癌、乳腺癌、前列腺癌、卵巢癌等多种肿瘤的发生发展和侵袭、转移过程,其表达可能与肿瘤病人的预后相关。目前HAS成为了肿瘤机制研究、肿瘤治疗靶点选择及评估预后的热点问题。Hyaluronan synthase（HAS） is a bifunctional glycosyltransferase distributed in the plasma membrane and plays a specific role in the synthesis of hyaluronic acid （HA）. It involves in the regulation mechanisms in the oncogenesis, invasion and metastasis of a variety of tumors, such as colorectal cancer, breast cancer, prostate cancer and ovarian cancer by inhibiting apoptosis, promoting cell adhesion and epithelial-mesenchymal transition （EMT） and increasing O-GIcNAc glycosylation. Its expression was related to the prognosis of cancer patients. Currently, it has more concern in the functions of HAS in the mechanism of tumor, tumor therapeutic target selection and the prognostic evaluation.

关 键 词：合酶 肿瘤病 细胞生长 细胞粘附 乳腺癌骨转移 GLCNAC 特异性作用 糖基化修饰 粘附作用 细胞外基质 

分 类 号：R730.2[医药卫生—肿瘤]