Molecular mechanisms of NMDA receptor-mediated excitotoxicity:implications for neuroprotective therapeutics for stroke  

作　　者：Victor Li Yu Tian Wang 

机构地区：[1]Djavad Mowafaghian Centre for Brain Health and Department of Medicine,Vancouver Coastal Health Research Institute,University of British Columbia Vancouver

出　　处：《Neural Regeneration Research》2016年第11期1752-1753,共2页中国神经再生研究（英文版）

摘　　要：Excitotoxicity is a process observed in many disease states by which an excessive synaptic excitation causes neuronal death, and is thought to be triggered by the extracellular accumulation of the excitatory neurotransmitter glutamate, which binds and activates ionotropic N-methyl-D-aspartate glutamatergic receptors （NMDARs） in the brain. Normally, NMDARs mediate calcium entry into the cell to regulate physiological processes such as synaptic plasticity and memory,Excitotoxicity is a process observed in many disease states by which an excessive synaptic excitation causes neuronal death, and is thought to be triggered by the extracellular accumulation of the excitatory neurotransmitter glutamate, which binds and activates ionotropic N-methyl-D-aspartate glutamatergic receptors （NMDARs） in the brain. Normally, NMDARs mediate calcium entry into the cell to regulate physiological processes such as synaptic plasticity and memory,

关 键 词：NMDAR Molecular mechanisms of NMDA receptor-mediated excitotoxicity 

分 类 号：R743.3[医药卫生—神经病学与精神病学]