克伦特罗在猪尿液中的消除规律研究  

Study on Elimination Rule of Clenbuterol in Swine Urine

作　　者：张倩[1] 颜显辉 管恩平[1] 唐正浩 

机构地区：[1]黄岛出入境检验检疫局,山东青岛266444 [2]荣成出入境检验检疫局,山东荣成264300 [3]烟台龙大食品有限公司,山东烟台264000

出　　处：《中国动物检疫》2016年第12期31-33,42,共4页China Animal Health Inspection

基　　金：国家质量监督检验检疫总局科学研究和技术开发项目(2011IK189)

摘　　要：[目的 ]研究克伦特罗在猪尿液中的消除规律。[方法 ]用含有克伦特罗1.5 mg/kg的饲料,饲喂一组体重约50 kg的90日龄育肥猪,正常饲喂35天后停药,收集停药后前32天的猪尿液,采用高效液相色谱法(HPLC)进行克伦特罗含量分析。[结果 ]停药后的前4天,猪尿液中的克伦特罗浓度迅速下降,第4天降至13.23μg/kg,之后消除速度放慢,第32天为0.44μg/kg,仍然高于最低检测限0.05μg/kg。[结论 ]克伦特罗在猪体内消除缓慢,容易蓄积。Objective] In order to study the elimination rule of Clenbuterol in swine urine. [Methods] A group of 50 kg,90-day-old fattening pigs were fed on feed containing Clenbuterol of 1.5 mg/kg,the experiment of feeding drugs was conducted for 35 days totally. After drug withdrawal,the prior 32-day swine urine samples were collected and the content of Clenbuterol was analyzed by high performance liquid chromatography（HPLC）. [Results] The concentration of Clenbuterol in the urine dropped down quickly in 1~4 days after drug withdrawal,and in the fourth day,it was down to 13.23 μg/kg,then the elimination rate slowed down and in the thirty-second day,it was 0.44 μg/kg,which was still higher than the minimum detection limit of 0.05 μg/kg. [Conclusion] The results showed that Clenbuterol eliminated slowly and accumulated easily in pigs.

关 键 词：克伦特罗 猪 尿液 消除 

分 类 号：S851.43[农业科学—预防兽医学]