利用^131I治疗分化型甲状腺癌肺转移患者的疗效评价及相关因素分析  

Effect evaluation and correlation factors of ^131I in treatment of patients with differentiated thyroid carcinoma with pulmonary metastasis

作　　者：弓彦伟 陈永辉[2] 于南[3] 

机构地区：[1]榆林市第一医院核医学科,719000 [2]北京协和医院核医学科,100032 [3]四川大学华西医院核医学科,成都610041

出　　处：《国际呼吸杂志》2016年第22期1707-1709,共3页International Journal of Respiration

摘　　要：目的 研究分析^ 131 I 治疗分化型甲状腺癌肺转移患者的疗效评价及相关因素。方法选取 2005 年 1 月至 2015 年 1 月在榆林市第一医院、北京协和医院及四川大学华西医院治疗的分化型甲状腺癌肺转移患者 82 例作为研究对象,在接受甲状腺癌手术后,采用^ 131 I 对其进行治疗,观察治疗3 个月后的短期疗效,并分析影响疗效的相关因素。结果 随着治疗次数的增加,患者的缓解率呈逐渐下降的趋势。分析^ 131 I 治 疗效 果的 影 响因 素,与 男 性相 比,女 性 患者 的治 疗缓 解 率较 高 （χ^2 =5.707 , P 〈0.05 ）,且治疗前血清甲状腺球蛋白水平较低的患者治疗缓解率明显高于水平较高的患者（χ^2 =3.934 ,P 〈0.05 ）。进一步分析可见,治疗前甲状腺球蛋白水平是影响患者治疗效果的主要因素之一,缓解组与未缓解组比较差异有统计学意义 （ t =8.462 , P 〈0.05 ）。经多元 logistic 回归分析,^131I 的治疗效果与患者治疗前甲状腺球蛋白呈明显负相关。结论 ^131 I 对分化型甲状腺癌肺转移患者有十分显著的疗效,且患者性别、治疗前血清甲状腺球蛋白水平是影响其疗效的相关因素。Objective To explore the therapeutic effect of ^131I in the treatment of differentiated thyroid carcinoma with pulmonary metastasis and the related factors. Methods 82 patients with differentiated thyroid carcinoma with pulmonary metastasis treated in the First Hospital of Yulin, Peking Union Medical College Hospital and West China Hospital of Sichuan University from January 2005 to January 2015 were selected as the research objects. After the operation of thyroid cancer, ^131I was used to treat the patients with thyroid cancer. The short term effect was observed after treatment for three months, and the related factors were analyzed. Results Along with the increase of the numbers of treatment, the remission rate of the patients was gradually decreased. The effect of ^131I on the treatment of female patients was significantly higher than that of male patients. Further analysis showed that the level of thyroglobulin in the no remission group was significantly higher than that in the remission group （ t = 8.462, P〈0.06）. The multivariate logistic regression analysis showed that the effect of ^131I on the treatment of patients was significantly negative correlated with thyroglobulin level before treatment （ P〈0.05）.Concluslons ^131I has a very significant effect on the patients with differentiated thyroid carcinoma with pulmonary metastasis, and the serum level of thyroglobulin before treatment and sex are the related factors that influence the treatment effect.

关 键 词：^131I 分化型甲状腺癌 肺转移 疗效 相关因素 

分 类 号：R736.1[医药卫生—肿瘤]