肿瘤干细胞的研究进展  

Research progress on cancer stem cells

作　　者：常克杰 李兵[1] 

机构地区：[1]第二军医大学长征医院呼吸内科,上海200003

出　　处：《国际呼吸杂志》2016年第22期1744-1749,共6页International Journal of Respiration

基　　金：国家自然科学基金资助项目（81172227）

摘　　要：肿瘤干细胞是指肿瘤组织中存在的一小群具有自我更新能力和多向分化潜能的细胞。肿瘤干细胞主宰着肿瘤分化、癌细胞增殖、自我更新及血管形成等诸多方面。如果能够有效抑制肿瘤干细胞，就可以从源头上阻断恶性肿瘤的发生、发展。本文对肿瘤干细胞的起源、肿瘤干细胞学说的发展、肿瘤干细胞与肿瘤异质性、转移和耐药的关系以及针对肿瘤干细胞的治疗策略等方面进行综述，为未来肿瘤的诊断和治疗提供新思路。Cancer stem cells （CSCs） are small groups of cells with selLrenewal capacity and multi differentiation potential in tumor tissues. They dominate the differentiation of tumors, proliferation of cancer ceils, self-renewal and angiogenesis, and so on. If CSCs can be effectively suppressed, the initiation and development of tumors will be blocked from the origin. This paper mainly reviews the origin of CSCs, the development of CSCs theory, the relationship between CSCs and cancer heterogeneity, metastasis and drug resistance, and CSCs-targeted therapeutic strategies to provide some new ideas for the clinical diagnosis and treatment of cancer in the future.

关 键 词：肿瘤干细胞 起源 肿瘤异质性 转移 耐药 治疗策略 

分 类 号：R730.2[医药卫生—肿瘤]