丹参多酚酸盐辅助治疗对急性冠脉综合征患者血小板膜糖蛋白CD62p和CD63水平的影响及疗效观察  

Influence and Curative Effect of Salvianolate Adjuvant Therapy on Platelet Membrane Glycoprotein CD62p and CD63 Levels in Patients with Acute Coronary Syndrome

作　　者：林杨闯[1] 余祖善[1] 

机构地区：[1]台州市立医院心内科,浙江台州318000

出　　处：《中国药师》2016年第12期2335-2336,2338,共3页China Pharmacist

基　　金：浙江省医学会基金项目(编号:2013ZYC-A140)

摘　　要：目的:探讨丹参多酚酸盐辅助治疗对急性冠脉综合征(ACS)患者血小板膜糖蛋白CD62p和CD63水平的影响及其疗效。方法:ACS患者89例随机分为观察组45例和对照组44例。两组均按ACS常规治疗方案治疗;观察组在此基础上加用注射用丹参多酚酸盐注射液200 mg,ivd,qd,均连用2周。比较两组患者治疗前后血小板膜糖蛋白CD62p、CD63水平变化,观察两组心脏缺血相关事件发生率及药品不良反应。结果:两组治疗中分别脱落2例和1例,脱落率比较差异无统计学意义(P>0.05)。治疗2周后,两组患者血小板膜糖蛋白CD62p、CD63水平均较前明显下降(P<0.05或P<0.01),且观察组明显低于对照组(P<0.05)。观察组治疗期间心脏缺血相关事件发生率明显低于对照组(P<0.05)。两组药品不良反应均较轻微,发生率比较无明显差异(P>0.05)。结论:丹参多酚酸盐辅助治疗ACS患者疗效确切,安全性较佳,能降低心脏缺血相关事件发生率,机制可能与其能降低血小板膜糖蛋白CD62P和CD63的水平,从而抑制血小板活化密切相关。Objective： To explore the influence and curative effect of salvianolate adjuvant therapy on the platelet membrane glycoprotein levels in the patients with acute coronary syndrome （ACS）. Methods： Totally 89 cases with ACS were divided into the observation group and the control group. The patients in two groups were given ACS medical treatment, and the patients in the observation group were additionally given 200rag salvianolate, once a day for 2 weeks. The level changes of platelet membrane glyeoprotein CD62p and CD63 in the two groups were compared, and the occurence rate of cardiac ischemia related events and adverse drug reactions were evaluated as well. Results： Two cases and one case fell off respectively in the control group and the observation group without statistical difference （P 〉 0.05）. After the 2-week medical treatment, the platelet membrane glycoprotcin CD62p and CD63 levels in both groups obviously declined than those before the treatment （ P 〈 0.05 ）, and the declining rates in the observation group were much higher than those in the control group （ P 〈 0.05 ）. Meanwhile, the occurrence rate of cardiac ischemia related events in the observation group during the treatment was much lower than that in the control group （ P 〈 0.05 ）. Three and two cases of untoward effect with light symptom appeared respectively in the observation group and the control group without obvious difference （P 〉 0.05 ）. Conclusion ： Salvianolate adjuvant therapy has reliable curative effect and favorable security in the patients with ACS, which can reduce the occurrence rate of cardiac ischemia related events, and the mechanism of action may have close relationship with reducing the platelet membrane glycoprorein CD62p and CD63 levels resulting in the platelet activation inhibition.

关 键 词：急性冠状动脉综合征 丹参多酚酸盐 血小板膜糖蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]