血管内皮生长因子与雌激素受体α在子宫内膜腺癌中的表达意义  

The Expression of Vascular Endothelial Growth Factor and Estrogen Receptor Alpha in Endometrial Adenocarcinoma

作　　者：王丹[1] 王薇[1] 裴丽杨[1] 赵艳梅[1] 王凤英[1] 

机构地区：[1]大庆市人民医院妇产科,黑龙江大庆163316

出　　处：《中国继续医学教育》2016年第32期42-43,共2页China Continuing Medical Education

摘　　要：目的 探讨血管内皮生长因子与雌激素受体α在子宫内膜腺癌中的表达意义。方法 回顾性分析2014年2月-2016年3月本院确诊的32例子宫内膜腺癌患者的临床资料,将其纳入观察组,再以诊断性刮宫的正常子宫内膜32例作为对照组。比较两组患者病理诊断中血管内皮生长因子与雌激素受体α阳性率。结果 观察组32例患者中,血管内皮生长因子阳性20例,雌激素受体α阳性23例。对照组32例患者中,血管内皮生长因子阳性8例,雌激素受体α阳性12例。观察组血管内皮生长因子及雌激素受体α阳性均高于对照组,差异有统计学意义（P〈0.05）。结论 子宫内膜腺癌患者病理血管内皮生长因子与雌激素受体α阳性较正常组织明显增加。Objective To investigate the expression of vascular endothelial growth factor and estrogen receptor alpha in endometrial adenocarcinoma. Methods The clinical data of 32 patients with adenocarcinoma of the uterus diagnosed in our hospital from February 2014 to March 2016 were analyzed retrospectively, which were included in the observation group, by diagnostic curettage and 32 cases of normal endometrium as control group. The expression of vascular endothelial growth factor and estrogen receptor positive rate were compared between two groups.Results In the observation group, 32 cases were observed, vascular endothelial growth factor was positive in 20 cases and estrogen receptor positive in 23 cases. Control group of 32 patients, vascular endothelial growth factor positive in 8 cases, estrogen receptor alpha positive in 12 cases. The expression of vascular endothelial growth factor and estrogen receptor positive in the observation group were higher than that in the control group, the difference was statistically significant （P〈0.05）.Conclusion The expression of vascular endothelial growth factor and estrogen receptor in endometrial adenocarcinoma was signiifcantly increased compared with that in normal tissue.

关 键 词：子宫内膜腺癌 血管内皮生长因子 雌激素受体Α 

分 类 号：R737.33[医药卫生—肿瘤]