研究阿立哌唑替换利培酮治疗对精神分裂症患者血清催乳素水平的影响  

The Effect of Aripiprazole on Replacement of Risperidone in the Treatment of Serum Prolactin Levels in Female Schizophrenia Patients

作　　者：赵晓玲[1] 

机构地区：[1]江苏省南通市紫琅医院精神科,江苏南通226000

出　　处：《中国继续医学教育》2016年第32期194-195,共2页China Continuing Medical Education

摘　　要：目的观察阿立哌唑替换利培酮对精神分裂症患者治疗期血清催乳素水平的影响。方法选取我院2016年1~7月收治的精神分裂症患者100例作为研究对象,按就诊时间先后分为两组,每组各50例患者。观察组使用阿立哌唑治疗,对照组使用利培酮治疗。比较两组患者在治疗期间的血清催乳素变化。结果经5周治疗后,观察组血清催乳素含量为(6.41±1.04)ng/ml,与治疗前比较,下降量为(24.18±2.64)ng/ml;对照组为(38.17±1.67)ng/ml,与治疗前比较,上升量为(6.73±2.46)ng/ml,治疗后两组患者血清催乳素水平对比,差异具有统计学意义(P<0.05)。观察组BMI值为(28.14±1.34)kg/m^2,对照组为(27.54±1.84)kg/m^2,两组数据对比,差异具有统计学意义(P<0.05)。结论使用阿立哌唑对精神分裂症患者进行治疗,可有效降低体内血清催乳素含量,提升疗效。Objective To observe the effect of aripiprazole replacement risperidone on serum prolactin levels in patients with schizophrenia treatment.Methods 100 cases of schizophrenia in our hospital from January to July 2016 in our hospital were selected as study subjects. According to the treatment time has been divided into two groups, 50 cases of patients in each group. The observation group was treated with aripiprazole, the control group was treated with risperidone. The change of serum prolactin in two groups were compared.ResultsAfter 5 weeks of treatment, the observation group serum prolactin content （6.41 ± 1.04） ng/ml, compared with before treatment decreased weight （24.18 ± 2.64） ng/ml control group, the average content is （38.17 ± 1.67） ng/ml, compared with before treatment increased weight （6.73 ± 2.46） ng/ml, there were significant differences two groups of patients with serum prolactin levels after treatment with statistical signiifcance,P 〈0.05. Observation group BMI （28.14 ± 1.34） kg/m2, the control group （27.54 ± 1.84） kg/m2, two groups of data comparison, the difference was statistically signiifcant （P 〈 0.05）.Conclusion The use of aripiprazole on schizophrenia patients, which can effectively reduce the serum prolactin levels in the body and enhance the effcacy.

关 键 词：阿立哌唑 利培酮 精神分裂症 血清催乳素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]