实时组织超声弹性成像对肝硬化的应用价值研究  

Application value of Real-time tissue elastog-raphy in liver cirrhosis

作　　者：刘丽琴[1] 熊慧妮[1] 孙翔[1] 谭杰[1] 

机构地区：[1]武汉市汉口医院超声影像科,武汉430050

出　　处：《肝胆外科杂志》2016年第5期350-353,共4页Journal of Hepatobiliary Surgery

摘　　要：目的探讨实时组织超声弹性成像（Real-timetissueelastog-raphy，RTE）技术和常规超声检查（Routineultrason—icinspection，RUI）对肝硬化的应用价值。方法选取2014年4月～2016年2月在本院进行人院治疗的肝硬化患者92例作为研究对象，根据其病情严重程度分为早期代偿期肝硬化组71例以及失代偿期肝硬化组21例。以肝组织取活检病理临床诊断结果作为金标准，应用SPSS21．0统计学软件计算并采用Z检验比较常规超声积分和实时RTE技术诊断代偿期肝硬化、失代偿期肝硬化的ROC曲线下面积。结果将92例确诊的肝硬化患者作为肝硬化组，数据分析结果表明RTE技术诊断肝硬化的ROC曲线下面积（0．971）、敏感度（95．42％）、特异度（93．38％）均显著大于RUI积分诊断（依次为0．846、72．46％、86．61％），具有显著性差异（Z／x2值依次为2．844、3．127、2．547，P〈0．05）；RTE技术诊断早期代偿期肝硬化的ROC曲线下面积（0．956）、敏感度（94．58％）、特异度（93．07％）均显著大于RUI积分诊断（依次为0．738、51．65％、87．46％），具有显著性差异（Z／X。值依次为3．639、5．174、2．429，P〈0．05）；RTE技术诊断失代偿期肝硬化的ROC曲线下面积、敏感度、特异度与RUI积分诊断比较均不具有显著性差异。结论与RUI相比较，RTE技术诊断早期代偿期肝硬化具有显著优势，但对失代偿期肝硬化患者进行诊断时效果无明显差异。Objective To dicuss the application value of RTE technology and RUI in liver cirrhosis. Methods 92 cases of liver cirrhosis patients were selected in our hospital from Apr 2014 to Feb 2016 as the research objects, according to the severity of the disease were divided into early compensated cirrhosis group 71 cases and cirrhosis of the liver group 21 patients. Using liver biopsy as the gold standard, SPSS21 statistical software was used to calculate and compare the ROC curve area under the Z curve for the diagno- sis of compensated cirrhosis and cirrhosis by real-time RTE test. Results 92 patients with cirrhosis were diagnosed as cirrhosis group, the results of data analysis showed that the RTE technology for diagnosis of liver cirrhosis area under ROC curve （0. 971 ）, sensitivity（95.42%） and specificity （ 93.38% ） were significantly higher than the RUI integral diagnosis （ respectively 0. 846, 72.46%, 86.61% ）, the difference was statistically significant （The values of Z/X2 were 2. 844,3. 127,2. 547 respectively, P 〈 0. 05 ） ; the RTE technology for diagnosis of early compensated cirrhosis area under ROC curve （0. 956 ）, sensitivity （94. 58% ） and specificity （93.07%） were significantly higher than the RUI integral diagnosis （respectively 0. 738,51.65% , 87. 46% ）, the difference was sta- tistically significant（The values of Z/X2 were 3. 639,5. 174,2.429 respectively, P 〈 0.05 ） ; The area, sensitivity, specificity and RUI score of ROC in the diagnosis of the RTE curve in the patients with non compensatory cirrhosis were not significantly different. Conclu- sion Compared with RUI, RTE technique has a significant advantage in the diagnosis of early compensatory cirrhosis,but there was no significant difference in the diagnosis of the patients with non compensatory cirrhosis.

关 键 词：实时组织超声弹性成像 常规超声检查 代偿期肝硬化 失代偿期肝硬化 

分 类 号：R575[医药卫生—消化系统]