临床上治疗酒精性肝病的药物使用  

Clinical medications for alcoholic liver disease

作　　者：许美娟[1] 陈赞雄[2] 李耀才[3] 叶建文[1] 周华胜[4] 

机构地区：[1]茂名市人民医院药剂科,广东茂名525000 [2]茂名市人民医院消化科,广东茂名525000 [3]茂名市人民医院传染科,广东茂名525000 [4]茂名市人民医院检验科,广东茂名525000

出　　处：《广州医科大学学报》2016年第4期27-29,共3页Academic Journal of Guangzhou Medical University

摘　　要：目的：研究治疗酒精性肝病的几种药物在临床上的使用情况。方法：选取茂名市人民医院在2014年12月至2015年12月间的酒精性肝病患者180例，按照随机数字法分为A、B、C三组，三组各60例，在所有患者均遵循严格戒酒的基础上，A组患者采用1．0克思美泰加入5％的250 mL葡萄糖液，每日一次，B组患者采用美他多辛口服，每次500 mg，每天三次，C组采用静脉滴注复方甘草酸苷，每次40～80 mL。结果：三组患者在治疗前后ALT、AST、TBIL、GGT等肝指标变化程度差异无统计学意义，在临床疗效方面三组患者的总有效率差异无统计学意义（P＞0．05）。结论：思美泰、美他多辛、复方甘草酸苷在酒精性肝病的治疗过程中有着显著的疗效，且疗效相似，均可以用于临床上治疗酒精性肝病，值得在临床上推广。Objective：To investigate the clinical medications for alcoholic liver disease in our hospital. Methods：Included in this study were 180 patients with alcoholic liver disease in our hospital between December 2014 and December 2015. By random digital table,the patients were divided into groups A,B and C （n=60 each）. All patients were instructed to be on strict abstinence of alcohol. Group A was given intravenous Transmetil 1. 0 g in 250 mL of 5%glucose solution,once daily;Group B received oral Metadoxine 500 mg for three times daily. Group C was given intravenous Compound Glycyrrhizin 40-80 mL per time. Results：The three groups of patients did not show any significant change from baseline in ALT,AST,TBIL and GGT. The overall clinical effectiveness rate was comparable among the three groups （P〉0.05）.Conclusion：Transmetil,Metadoxine and Compound Glycyrrhizin are significantly and comparably effective in the treatment of alcoholic liver disease, and therefore are justified for widespread use in clinical practice.

关 键 词：酒精性肝病 思美泰 美他多辛 复方甘草酸苷 临床疗效 

分 类 号：R575.2[医药卫生—消化系统]