动态增强MR成像在前列腺癌中的应用进展  

Progress in application of dynamic contrast-enhanced MRI in diagnosing prostate cancer

作　　者：王洁琼[1] 王青[1] 徐兴华[1] 张玉梅[1] 何敬振[1] 

机构地区：[1]山东大学齐鲁医院放射科,济南250012

出　　处：《国际医学放射学杂志》2016年第6期657-660,共4页International Journal of Medical Radiology

基　　金：山东省科技发展计划项目(2013GGE27063);山东省青年自然科学基金(ZR2015HQ017)

摘　　要：新生血管生成是前列腺癌发生、发展及转移的重要因素之一,动态增强MRI(DCE-MRI)通过采集对比剂注入前、中、后的组织影像信息,可获得时间-信号强度曲线、半定量及定量灌注参数,反映肿瘤组织的微循环及血流灌注变化,以实现对前列腺癌的定量分析。就DCE-MRI在前列腺癌定性诊断、半定量及定量分析、分期诊断及疗效评估方面的价值及研究进展予以综述。Angiogenesis plays an important role in the growth, progression and metastasis of prostate cancer. Dynamic contrast-enhanced MRI（DCE-MRI） can be used to plot the time signal intensity curve and calculates the semi-quantitative and quantitative perfusion parameters by gathering graphic information pre-, during- and after- contrast agent injection,reflecting the microcirculatory and hemodynamic changes of tumor tissue, thus can be used to quantatively analysize prostate cancer. This paper describes research progress of DCE-MRI in qualitative diagnosis, semi-quantitative and quantitative analysis, staging, and therapeutic efficacy in prostate cancer.

关 键 词：前列腺癌 动态增强磁共振成像 药动学 灌注 

分 类 号：R737.25[医药卫生—肿瘤] R445.2[医药卫生—临床医学]