计算机认知矫正治疗对创伤后应激障碍患者的辅助疗效  

Auxiliary effect of computerized cognitive remediation therapy( CCRT ) on sufferers with post-traumatic stress disorder

作　　者：伍晓凡[1] 张鹏[1] 刘立志[1] 梁学军[1] 范亮亮[1] 

机构地区：[1]解放军第91医院全军精神疾病防治研究所,454003

出　　处：《中国疗养医学》2017年第1期9-11,共3页Chinese Journal of Convalescent Medicine

基　　金：济南军区后勤科研计划课题(CJN10L052)

摘　　要：目的探讨计算机认知矫正治疗(CCRT)合并小剂量的奥氮平对创伤后应激障碍(PTSD)患者的疗效。方法将在解放军第91医院精神科住院的72例PTSD患者随机分为两组,研究组36例(计算机认知矫正治疗合并奥氮平),对照组36例(单用奥氮平治疗)。于治疗前、治疗3周末、6周末采用简明精神病评定量表(BPRS)、汉密顿抑郁量表(HAMD)和汉密顿焦虑量表(HAMA)分别进行评定,以治疗副反应量表(TESS)评定副反应。结果治疗3周末、6周末两组BPRS、HAMD和HAMA总分均显著低于治疗前(P<0.01),但研究组6周末总分显著低于对照组(P<0.05);研究组治疗6周末总有效率80.6%,显著高于对照组63.9%(χ~2=2.89,P<0.05);两组副反应差异无统计学意义(χ~2=1.76,P>0.05)。结论计算机认知矫正治疗对PTSD患者治疗不仅具有增效作用,并且具有更好的远期疗效。Objective To investigate the curative effect of computerized cognitive remediation therapy（CCRT） com- bined with small dose of olanzapine to treat post-traumatic stress disorder（PTSD）.Methods 72 cases with PTSD hos- pitalized at Psychiatry Department of No.91 PLA Hospital were randomly divided into study group （CCRT combined with olanzapine） and control group（olanzapine alone）with 36 cases in each group.The patients were evaluated respec- tively prior to treatment, 3 weeks and 6 weeks after treatment by means of Brief Psychiatric Rating Scale （BPRS）, Hamilton Depression Scal（HAMD） and Hamilton Anxiety Scale（HAMA）, and the side reaction was evaluated by treat- ment emergent symptom scale（TESS）.Flesults At the end of 3 weeks and 6 weeks of treatment,the scores of BPRS, HAMD and HAMA were significantly lower than those before treatment in both groups（P〈0.01）,but the scores of the study group at the end of 6 weeks were significantly lower than those of the control group（P〈0.05）;The total ef- fective rate in the study group at the end of 6 weeks was 80.6% ,which was significantly higher than 63.9% in the control group （χ2 = 2.89, P〈 0.05）;The side reaction in both groups showed no difference of statistical significance （χ2= 1.76, P〉0.05）.Conclusion Computerized cognitive remediation therapy（CCRT） not only shows synergism for sufferers with PTSD, but also bears better long-term therapeutic effect.

关 键 词：计算机认知矫正治疗 奥氮平 创伤后应激障碍 临床疗效 

分 类 号：R749.5[医药卫生—神经病学与精神病学]