血清和支气管灌洗液高迁移率族蛋白-1水平对于肺癌患者早期诊断和预后评估的研究  

The diagnosis value of HMGB- 1 in serum and bronchial lavage fluids in patients with lung cancer

作　　者：范瑞华[1] 郭佳妮[1] 姚榕[1] 黄明德[1] 

机构地区：[1]南京医科大学附属淮安第一医院肿瘤内科,江苏淮安224000

出　　处：《临床和实验医学杂志》2016年第23期2319-2322,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血清和支气管灌洗液高迁移率族蛋白-1（HMGB-1）水平对于肺癌患者早期诊断和预后评估的研究。方法连续性收录50例肺癌患者,以及50例肺部良性病变患者。检测血清和支气管灌洗液中HMGB-1水平改变,分析其与肿瘤分期、淋巴结以及远处组织转移情况等相关性。结果肺癌组中血清及支气管灌洗液内HMGB-1水平明显高于良性肺病组（P〈0.05）。肺癌患者支气管灌洗液中HMGB-1浓度高于血清浓度（P〈0.05）。TNM分期Ⅰ-Ⅱ期患者血清及支气管灌洗液HMGB-1明显低于Ⅲ-Ⅳ期患者（P〈0.05）;有淋巴结转移患者血清及支气管灌洗液HMGB-1明显高于无淋巴结转移患者（P〈0.05）;有远处转移患者血清及支气管灌洗液HMGB-1明显高于无远处转移患者（P〈0.05）。血清HMGB-1诊断肺癌的AUC为0.766,临界值为4.8 ng/ml;而支气管灌洗液HMGB-1水平诊断肺癌的AUC为0.834,临界值为12.5 ng/ml。血清和支气管灌洗液HMGB-1水平与肺癌呈正相关。结论肺癌患者血清和支气管灌洗液中HMGB-1水平明显上升,与肺癌的严重程度呈正相关,检测HMGB-1水平有助于肺癌的早期诊断和分期预测。Objective To estimate the diagnosis value of HMGB- 1 in serum and bronchial lavage fluids in patients with lung cancer.Methods Fifty lung cancer patients and fifty pulmonary benign disease patients were enrolled in this study. The levels of HMGB- 1 in serum and bronchial lavage fluids were measured and recorded. Correlation analysis was used to evaluate the association between HMGB- 1 and tumor stage.Results The levels of HMGB- 1 in serum and bronchial lavage fluids in lung cancer group were significantly higher than those in control group.The contents of serum HMGB- 1 were higher than those of bronchial lavage fluids in lung cancer patients. In comparison with Stage III- IV patients,the HMGB- 1 levels of both serum and bronchial lavage fluids in I- II patients were increased. The lung cancer patients with lymphatic metastasis had a higher level of HMGB- 1 in serum and bronchial lavage fluids compared with those without lymphatic metastasis. ROC analysis showed that the AUC for lung cancer diagnosis of serum and bronchial lavage fluids of HMGB- 1 were 0. 766 and 0. 834 respectively. The cut-off value were 4. 8 ng / ml and 12. 5 ng / ml,respectively. Correlation analysis showed that both serum and bronchial lavage fluids of HMGB- 1were positively related with lung cancer. Conclusion The levels of serum and bronchial lavage fluids HMGB- 1 are elevated in lung cancer patients,which may be useful for early detection and stage prognosis.

关 键 词：肺癌 血清 支气管灌洗液 高迁移率族蛋白-1 早期诊断 

分 类 号：R734.2[医药卫生—肿瘤]