USP22和Akt在胃癌中的表达及临床意义  

Expression and clinical significance of USP22 and Akt in gastric cancer

作　　者：于金玲[1] 杨冬冬[2] 

机构地区：[1]哈尔滨医科大学附属第四医院老年病科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第四医院肿瘤外科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2016年第5期417-419,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术研究项目(12541551)

摘　　要：目的检测USP22与Akt在胃癌组织中的表达,并探讨二者在胃癌组织中表达的相关性及二者共表达与胃癌患者临床病理特征及预后的关系。方法收集125例胃癌患者的存档蜡块,应用免疫组化染色法检测USP22与Akt在胃癌组织中的表达。结果 USP22与Akt在胃癌组织中的表达呈正相关(P<0.05);USP22与Akt共表达与患者的性别、年龄、肿瘤大小无相关性,而与肿瘤分化程度、浸润深度、有无淋巴结转移、有无远处转移以及AJCC临床分期相关(P<0.05);USP22与Akt非共表达组患者5年生存率明显高于共表达组(P<0.05)。结论 USP22可能为Akt的上游基因,通过激活Akt通路来促进胃癌的进展。Objective To explore the relevance of USP22 and Akt in gastric cancer tissue and the influence of co-expression on the clinicopathological features and prognosis of the patients. Methods Formalin-fixed paraffin embedded specimens were collected from 125 gastric cancer patients. Immunohistochemistry was performed to analyze USP22 and Akt distribution. Results Positive correlation was found between the expression of USP22 and Akt in gastric cancer tis- sue （P 〈 0. 05 ）. Co-expression of USP22 and Akt was not relevant to sex, age and the size of tumor. However, the co-expression was significantly correlated to the differentiation, infiltrative depth, lymph node metastasis, distant metastasis and AJCC staging （ P 〈 0. 05 ）. The co-expression was the poor predictive factor of 5-year survival rate （ P 〈 0. 05 ）. Conclusion USP22 may be the upstream gene of Akt, and may promote the progression of gastric cancer through activating Akt pathway.

关 键 词：胃癌 USP22 AKT 

分 类 号：R735.2[医药卫生—肿瘤]