MRI T_(1ρ)值的测量在早期肝硬化诊断中的应用研究  

Application research of magnetic resonance T_(1ρ) value measurement in the diagnosis of early liver cirrhosis

作　　者：王雪[1] 刘松国[1] 韩广[1] 孟祥福[1] 

机构地区：[1]山东省临沂市中医医院医学影像科,山东临沂276003

出　　处：《中国中西医结合影像学杂志》2016年第6期631-634,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :探讨MRI T_(1ρ)WI对早期肝硬化的诊断价值。方法 :40例早期肝硬化患者(观察组)和25例健康体检者(对照组)均行常规MRI扫描,并根据不同的自旋锁定时间(10、20、40和80 ms)行4次屏气T_(1ρ)扫描。分别测量出观察组和对照组肝脏的T_(1ρ)值并进行对比;在对照组内分析受检者的年龄与肝脏T_(1ρ)值的相关性。结果:观察组平均T_(1ρ)值(56.0±4.0)ms明显高于对照组的(49.7±3.5)ms。观察组Child-Pugh肝功能改良分级A和B级的T_(1ρ)值分别与对照组比较,差异均有统计学意义(均P<0.05)。对照组年龄与肝脏T_(1ρ)值无明显相关性(r=0.18,P=0.58)。结论:T_(1ρ)值在量化诊断早期肝硬化时具有较高敏感性和可重复性。Objective：To explore the utility of magnetic resonance T1ρweighted imaging（T1ρI） in the diagnosis of early liver cirrhosis. Methods ：40 cases of early cirrhosis patients（observation subjects） and 25 healthy physical examination volunteers（control subjects） were performed with conventional MRI,then T1ρI was acquired from four breath-hold scans with different spin-lock times（10,20,40 and 80 ms）. The T1ρalues of the observation subjects and healthy control subjects were measured and compared respectively. The T1ρalues of CPS A and CPS B in the observation subjects were compared with healthy control subjects respectively. The correlation between T1ρalue and the subjects age was analyzed in the healthy control subjects. Results：The T1ρvalue of observation subjects（56.0 ms±4.0 ms） was significantly higher than the T1ρalue of healthy control subjects（49.7 ms±3.5 ms）. The T1ρalues of CPS A and CPS B in the observation subjects were significantly difference,compared with healthy control subjects respectively（P 〈0.05）. There was no significant correlation between the age of healthy subjects and liver T1ρalue in the control subjects（r=0.18,P=0.58）. Conclusion：T1ρalue in quantitative diagnosis of early liver cirrhosis has high sensitivity and repeatability.

关 键 词：T1ρ成像 自旋锁定 肝硬化 磁共振成像 

分 类 号：R575.2[医药卫生—消化系统] R445.2[医药卫生—内科学]