首发抑郁症患者神经质人格对记忆的影响及抑郁的中介作用  

Effects of neuroticism on memory in patients with first-episode depression and the mediating role of depression

作　　者：孙宁[1] 何小婷[2] 杜巧荣[1] 李忻蓉[1] 李素萍[1] 张克让[1] Sun Ning He Xiaoting Du Qiaorong Li Xinrong Li Suping Zhang Kerang(Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, China Department of Medical Psychology, Shanxi Medical University, Taiyuan 030001, China)

机构地区：[1]山西医科大学第一医院精神卫生科,太原030001 [2]山西医科大学医学心理学教研室,太原030001

出　　处：《中华行为医学与脑科学杂志》2016年第11期977-980,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81471379）;山西省高等学校科技创新项目（2013119）

摘　　要：目的探究首发抑郁症患者神经质人格和记忆的关系，以及抑郁症状在二者之间的中介作用。方法使用汉密尔顿抑郁量表17项（Hamiltondepressionratingscale．17，HAMD．17）、艾森克人格问卷（Eysenckpersonalityquestionnaire，EPQ）、可重复性成套神经心理测验（repeatablebatteryfortheassessmentofneumpsych010gicalstatus，RBANS）对278例首发抑郁症患者进行调查和评估。结果（1）神经质人格与HAMD．17总分呈正相关（r=0．30，P〈0．01），与即刻记忆、延时记忆呈负相关（r=-0．26，-0．30；均P〈0．01）；HAMD-17总分与即刻记忆、延时记忆呈负相关（r=-0．55，-0．44；均P〈0．01）。（2）抑郁症状在神经质人格与即刻记忆、延时记忆之间的中介效应差异有统计学意义（β=-0．521，-0．388；均P〈0．01）。即刻记忆中介效应与总效应之比为0．597，延时记忆中介效应与总效应之比为0．383。结论神经质人格会影响抑郁症患者的记忆，并通过抑郁症状间接作用于记忆。Objective To explore the relationship between neuroticism and memory in patients with first-episode depression and the mediating effect of depression in this relationship. Methods Hamilton de- pression rating scale （HAMD）, Eysenck personality questionnaire （EPQ）, repeatable battery for the assess- ment of neuropsychological status （RBANS） were used to evaluate 278 patients with first-episode depression. Results （ 1 ） Neuroticism was negatively correlated with immediate memory （ r= -0.26, P〈 0.01 ）, delayed memory （ r= -0.30,/}〈0.01 ） , and positively correlated with depressive symptom （ r = 0.30, P〈 0.01 ）. Depres- sive symptom was negatively correlated with immediate memory （r=- 0.55, P〈 0.01 ）, delayed memory （r= -0.44 ,P〈0.01 ）. （2） The effect of neuroticism on immediate memory and delayed memory was partially me- diated by depressive symptom （fl=-0.521,-0.388,P〈0.01 ）. The ratio of mediating effect to total effect in immediate memory was 0.597 ,and the ratio of mediating effect to total effect in delayed memory was 0.383. Conclusion Memory can be affected by neuroticism through the indirect effect of depression.

关 键 词：抑郁症 神经质 记忆 

分 类 号：R749.4[医药卫生—神经病学与精神病学]