伴抑郁与不伴抑郁的轻度认知功能障碍患者神经心理测验表现比较  

Neuropsychological performance in mild cognitive impairment patients with or without depression

作　　者：沈树红[1] 宋彦彦[1] 王少石[1] 

机构地区：[1]上海市第一人民医院分院神经内科,200081

出　　处：《中华老年心脑血管病杂志》2016年第12期1270-1274,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：上海市虹口区医学科研项目(1302-06)

摘　　要：目的比较伴抑郁的遗忘型轻度认知功能障碍(aMCI)与不伴抑郁的aMCI患者神经心理特点。方法根据流行病学调查用抑郁自评量表和老年抑郁量表选择符合伴抑郁的aMCI患者43例(伴抑郁组),随机选择不伴抑郁的aMCI患者43例(不伴抑郁组),社区正常老年人43例(对照组),通过一系列神经心理测试,比较3组受试者的认知缺损特点。结果伴抑郁组和不伴抑郁组认知筛查总分、记忆测试评分、语言测试评分、部分注意功能评分、部分执行功能评分明显高于对照组,差异有统计学意义(P<0.05,P<0.01);伴抑郁组患者部分注意功能评分、部分执行功能评分、Boston命名测验、结构评分与对照组比较,差异有统计学意义(P<0.05,P<0.01);伴抑郁组Mattis痴呆评估量表评分明显低于不伴抑郁组[(123.83±9.81)分vs(129.91±6.99)分,P<0.01],日常生活能力评分明显高于不伴抑郁组[(2.58±2.23)分vs(1.25±1.70)分,P<0.01]。其余测试伴抑郁组与不伴抑郁组差异无统计学意义(P>0.05)。结论伴抑郁的aMCI患者认知功能障碍较不伴抑郁aMCI患者严重且弥漫,抑郁使aMCI患者的注意能力减退更严重。Objective To compare the neuropsychological performance in amnestic mild cognitive impairment （aMCI） patients with or without depression. Methods Forty-three aMCI patients with depression served as a depression group,43 aMCI patients without depression served as a depression-free group, and 43 community healthy elderly people served as a control group in this study. Their cognitive impairment was compared after a series of neuropsychological testing. Resuits The scores of cognitive test, memory test, language test, selective attention test, selective execution test were significantly higher in depression group and depression-free group than in control group （P〈0. 05 ,P〈0.01）. The scores of selective attention test,selective execution test, Boston naming test,structure test were significantly lower in depression group than in control group （P〈0.05 ,P〈0.01）. The Mattis dementia rating scale score was significantly lower whereas the daily living capability score was significantly higher in depression group than in depression-free group （123.83±9.81 vs 129.91±6.99,P〈0.01;2.58±2.23 vs 1.25±1.70,P〈0. 01）. No significant difference was found in other tests between the two groups （P〉0.05）. Conclusion Cognitive and attention impairments are severer in aMCI patients with depression than in those without depression.

关 键 词：认知障碍 抑郁 神经心理学测验 痴呆 记忆障碍 精神障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]