保乳手术与改良根治术治疗早期乳腺癌临床疗效的比较  

Efficacy of breast-conserving surgery vs modified radical mastectomy for early-stage breast cancer

作　　者：赵长啸[1] 董力[1] 

机构地区：[1]江苏省徐州市肿瘤医院乳腺科,徐州221005

出　　处：《中国肿瘤临床与康复》2016年第11期1316-1318,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨保乳手术与改良根治术治疗早期乳腺癌的临床效果。方法选取2011年12月至2013年11月间江苏省徐州市肿瘤医院收治的90例早期乳腺癌患者,采用随机数字表法分为观察组和对照组,每组45例。观察组患者采用保乳手术,对照组患者采用改良根治术。对比两组患者围手术期指标、术后上肢淋巴水肿发生率、术侧上肢功能受限率、术后疼痛率及随访3年的并发症发生率、局部复发率、远处转移率、死亡率、乳腺癌生活质量量表(QLQ-BR23)评价结果。结果观察组患者手术时间及住院时间缩短,术中出血量较少,与对照组比较,差异有统计学意义(P<0.05)。观察组患者术后上肢淋巴水肿发生率、术侧上肢功能受限率及术后疼痛率较低,与对照组比较,差异有统计学意义(P<0.05)。观察组患者并发症发生率较低,与对照组比较,差异有统计学意义(P<0.05)。观察组患者局部复发率、远处转移率降低,与对照组比较,差异无统计学意义(P>0.05)。观察组患者社会、情绪、角色、躯体功能评分较高,与对照组比较,差异有统计学意义(P<0.05)。结论保乳手术的临床疗效显著,缩短了手术时间,对周围组织创伤小,随访期间并发症发生率较低。Objective To probe into the clinical effectiveness of breast-conserving surgery vs modified radical mastectomy for early-stage breast cancer. Methods Select 90 patients with early-stage breast cancer treated at Xuzhou Cancer Hospital from December 2011 and November 2013. These patients were divided into a control group and an observation group with 45 patients in each group. Patients in the observation group were given breast-conserving surgery while patients in the control group were given modified radical mastectomy. Perioperative indicators,incidence of postoperative upper limb lymphedema,limitation upper limb function at surgical site,severe postoperative pain,and incidence of complications,local recurrence,distant metastases,mortality rate and QLQ-BR23 scores over 3 years followed-up were compared between the two groups. Results Compared with the control group,observation group had less operative time,shorter hospital stay and less intraoperative blood loss（ P〈0. 05）. Compared with the control group,the observation group had less postoperative incidence of upper limb lymphedema,limited upper limb function at surgical site and postoperative pain（ P〈0. 05）. Incidence of complications was lower in the observation group than the control group（ P〈0. 05）. There was no obvious difference in local recurrence,distant metastasis and mortality between the two groups（ P〉0. 05）. Social,emotional,role and body function scores were higher in the observation group compared with the control group（ P〈0. 05）. Conclusion Breast-conserving surgery shows efficacy for early-stage breast cancer,which shortens the operation time,with less surrounding tissue trauma and lower incidence of complications during the follow-up period compared with modified radical mastectomy.

关 键 词：乳腺肿瘤 保乳手术 改良根治术 治疗结果 

分 类 号：R737.9[医药卫生—肿瘤]