内分泌治疗联合经尿道前列腺电切术治疗晚期前列腺癌的疗效分析  

Efficacy of endocrine therapy combined with transurethral resection of prostate for advanced prostate cancer

作　　者：陈春雷[1] 陈伟杰[1] 梁国庆[1] 张蓓[1] 

机构地区：[1]上海市中医医院泌尿外科,上海200071

出　　处：《中国肿瘤临床与康复》2016年第11期1322-1324,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨内分泌治疗联合经尿道前列腺电切术(TURP)对晚期前列腺癌的生存影响。方法选取2010年3月至2015年3月间上海市中医医院收治的98例晚期前列腺癌患者,采用随机数字表法分为观察组和对照组,每组49例。观察组患者用内分泌治疗联合TURP治疗,对照组患者采用TURP治疗。治疗3个月后,比较两组患者的残余尿量(RV)、最大尿流率(Qmax)、国际前列腺症状评分(IPSS)和生活质量评分(QoL)等指标变化,比较两组患者总体生存率的差异。结果治疗3个月后,两组患者RV、IPSS和QoL等指标明显下降,差异均有统计学意义(均P<0.05)。Qmax水平明显增高,差异有统计学意义(P<0.05)。观察组患者的变化幅度明显高于对照组,差异有统计学意义(P<0.05)。观察组患者的总体生存率为55.1%,对照组为44.9%,组间差异无统计学意义(P>0.05)。结论内分泌治疗联合TURP能改善患者膀胱出口梗阻症状,疗效确切,不影响总体生存率,是提高晚期前列腺癌患者生活质量的首选治疗方案。Objective To investigate the effect of endocrine therapy combined with transurethral resection of prostate（ TURP） on the survival rate for advanced prostate cancer. Methods From March2010 to March 2015,98 patients with advanced prostate cancer were selected and randomly divided into an observation group and a control group at Shanghai Hospital of Traditional Chinese Medicine,with 49 patients in each group. Patients in the observation group received endocrine therapy combined with TURP,while patients in the control group only received TURP. After 3 months of treatment,residual urine volume（ RV）,maximum urinary flow rate（ Qmax）,International Prostate Symptom Score（ IPSS）,quality of life score（ Qo L） and other indicators were compared between the two groups. Difference of the overall survival rate was compared between the two groups. Results After 3 months treatment,RV,IPSS,Qo L and other indicators significantly decreased in the two groups（ P〈0. 05）. Qmax level significantly increased（ P〈0. 05）. Change in the observation group was significantly higher than the control group（ P〈0. 05）. The overall survival rate was 55. 1% for the observation group and 44. 9% for the control group（ P〉0. 05）.Conclusion Endocrine therapy combined with TURP can improve the symptoms of bladder outlet obstruction,with exact effectiveness and without affecting the overall survival rate. This is a preferred option to improve quality of life in patients with advanced prostate cancer.

关 键 词：前列腺肿瘤 生活质量 前列腺电切术 内分泌腺 

分 类 号：R737.25[医药卫生—肿瘤]