肝动脉栓塞化疗联合超声引导下瘤内无水酒精注射治疗对肝癌患者血清甲胎蛋白和生存情况的影响  

Effect of transcatheter arterial chemoembolization plus ultrasound guided percutaneous ethanol injection on serum α-fetoprotein and survival in patients with liver cancer

作　　者：袁征[1] 柯文炳 

机构地区：[1]鄂东医疗集团黄石市中心医院湖北理工学院附属医院超声影像科,黄石435000 [2]鄂东医疗集团黄石市中医院传染病医院感染科,黄石435000

出　　处：《中国肿瘤临床与康复》2016年第11期1331-1333,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨肝动脉栓塞化疗（TACE）联合超声引导下瘤内无水酒精注射（PEI）治疗对肝癌患者血清甲胎蛋白和生存情况的影响。方法选取2009年8月至2012年8月间湖北省黄石市中心医院收治的90例肝癌患者,采用随机数字表法分为观察组和对照组,每组45例。观察组患者在TACE治疗基础上联合PEI治疗,对照组患者仅采用TACE治疗。观察两组患者治疗效果、治疗前后血清甲胎蛋白（AFP）变化、1-3年生存率和复发率。结果观察组和对照组患者的缓解率分别为82.2%和64.4%,两组比较差异有统计学意义（P〈0.05）。治疗前两组患者血清AFP水平间差异无统计学意义（P〉0.05）,治疗后观察组患者血清AFP水平明显高于对照组,差异有统计学意义（P〈0.05）。观察组患者1、2和3年复发率分别为0、4.4%和13.3%;对照组分别为6.7%、15.6%和26.7%。观察组患者1、2和3年生存率分别为93.3%、84.4%和68.9%,对照组分别为82.2%、68.9%和48.9%,差异有统计学意义（P〈0.05）。结论 TACE联合超声引导下PEI治疗效果较好,能够明显降低肝癌患者的AFP水平,提高肝癌生存率,降低复发率,值得临床推广应用。Objective To explore the effect of transcatheter arterial chemoembolization（ TACE）plus ultrasound guided percutaneous ethanol injection（ PEI） on serum α-fetoprotein（ AFP） and survival in patients with liver cancer. Methods From August 2009 to August 2012,90 patients with liver cancer were enrolled at Huangshi Central Hospital and were randomly divided into two groups： an observation group and a control group,with 45 patients in each group. Patients in the observation group received TACE combined with ultrasound guided PEI and patients in the control group only received TACE. Treatment efficacy,changes of serum AFP before and after treatment,1 to 3-year survival and recurrence were observed in the two groups. Results The response rate were 82. 2% and 64. 4% for the observation group and the control group,respectively（ P〈0. 05）. Before treatment,the serum AFP of showed no difference in both groups（ P〉0. 05）. After treatment,the serum AFP in the observation group was significantly higher than that in the control group（ P〈0. 05）. The 1,2 and 3-year recurrence rates were 0,4. 4%,and 13. 3% for the observation group and 6. 7%,15. 6% and 26. 7% for the control group. The 1,2 and 3-year survival rates were 93. 3%,84. 4% and 68. 9% in the observation group,which were higher than 82. 2%,68. 9% and48. 9% of the control group（ P〈0. 05）. Conclusion TACE combined with ultrasound guided PEI shows good efficacy and can significantly reduce the level of serum AFP,improve survival and reduce the recurrence rate in patients with liver cancer. It is worthy of clinical application and promotion.

关 键 词：肝肿瘤 超声引导 甲胎蛋白 肝动脉栓塞药物疗法 

分 类 号：R735.7[医药卫生—肿瘤]