铝碳酸镁对反流性胃炎大鼠炎性因子及胃肠动力学的影响  

Influence of Hydrotalcite on Inflammatory Factors and Gastrointestinal Kinetics on Model Rats with Reflux Gastritis

作　　者：李兴红[1] 赵亮[2] 

机构地区：[1]恩施土家族苗族自治州利川市人民医院消化内科,湖北恩施445400 [2]武汉大学第一临床教学医院消化二科,湖北武汉430064

出　　处：《医学临床研究》2016年第11期2081-2083,2087,共4页Journal of Clinical Research

基　　金：湖北省自然科学基金资助项目（编号：SJ97J083）

摘　　要：【目的】探讨铝碳酸镁对反流性胃炎模型大鼠炎性因子及胃肠动力学的影响。【方法】选择SPF级Wistar大鼠36只为研究对象，随机分为正常组、模型组、铝碳酸镁组各12只，模型组、铝碳酸镁组均建立反流性胃炎模型。铝碳酸镁组给予1mL铝碳酸镁混悬液灌胃，正常组、模型组给予等量生理盐水灌胃。观察三组体重增长情况与食管系数、黏膜损伤评分，检测黏膜组织炎性因子、血清胃动力学指标。【结果】模型组体重增加明显低于正常组，食管系数、黏膜损伤评分明显高于正常组（t=10．543，13．247，19．611，P〈0．05），铝碳酸镁组体重增加量明显高于模型组，食管系数、黏膜损伤评分明显低于模型组（t=6．954，7．562，8．028，P〈0．05）；模型组黏膜组织肿瘤坏死因子a（TNF-a）、白细胞介素-8（IL-8）、细胞间黏附分子1（ICAM-1）明显高于正常组（t=3．605，10．709，6．603，P〈0．05），铝碳酸镁组黏膜组织TNF-a、IL-8、ICAM-1明显低于模型组（t=2．242，7．773，4．864，P〈0．05）；模型组血清胃泌素（GAS）、胃动素（MTL）含量明显低于正常组（t=3．934，4．785，P〈0．05），铝碳酸镁组血清GAS、MTL含量明显高于模型组（t=3．173，3．985，P〈0．05）。【结论】铝碳酸镁有助于下调反流性胃炎模型大鼠黏膜组织炎性因子含量，减少胃滤膜损伤，提高胃肠动功能。[Objective]To investigate the influence of hydrotaleite （a reagent like aluminum magnesium carbonate） on inflammatory factors and gastrointestinal kinetics of model rats with reflux gastritis. [Methods]A total of 36 SPF level Wistar rats were selected as the objects of study and randomly divided into the normal group, the model group, and the hydrotalcite group, with 12 rats in each group. Reflux gastritis model was established in both the model group and the hydrotalcite group. Rats in the hydrotalcite group were given lml hydrotalcite suspension for gavage administration, while rats in the normal group and the model group were given the equivalent a- mount of normal saline for gavage administration. The weight growth, esophageal coefficient, and score of mucosal injury of rats in the three groups were observed, and the inflammatory factors of mucosal tissues and serum gastric dynamics index were tested. [Results]The weight growth of the model group was significantly lower than the normal group, and the esophageal coefficient and score of mucosal injury were significantly higher than those of the normal group （ t =10.543, 13.247, 19.611, P 〈0.05）. the weight growth of the hydrotalcite group was significantly higher than the model group, and the esophageal coefficient and score of mucosal injury were significantly lower than those of the model group （ t =6.954, 7.562, 8.028, P 〈0.05）. The tumor necrosis factor alpha （TNF-a）, interleukin-8 （IL-8）, and intercellular adhesion molecule 1 （ICAM-1） of the mucosal tissues of the model group were significantly higher than in the normal group （ t = 3.605, 10.709, 6.603, P 〈0.05）. The TNF-a, IL-8, and ICAM-1 of the mucosal tissues of the hydrotalcite group were significantly lower than the model group （ t = 2.242, 7.773, 4.864, P 〈0.05）. The contents of serum gastrin （GAS） and motilin （MTL） of the model group were significantly lower than those of the normal group （ t = 3.934, 4.785, P 〈0.05） ; the contents of serum GAS

关 键 词：铝/治疗应用 碳酸盐类/治疗应用 胃炎/药物疗法 胆汁返流/药物疗法 胃肠活动 肿瘤坏死因子A 

分 类 号：R57[医药卫生—消化系统]