EORTC QLQ-STO22量表对我国胃癌患者有效性的验证  

The validation of EORTC QLQ-STO22 scale in patients with gastric cancer in China

作　　者：刘伟琳[1] 杨舸[1] 芮煜华 林允寿 王舒逸[3] 张雷[4] 

机构地区：[1]中南大学湘雅医学院,长沙410013 [2]天津医科大学基础医学院,300070 [3]浙江大学基础医学院,杭州310013 [4]天津市肿瘤医院肺部肿瘤科,300060

出　　处：《肿瘤研究与临床》2016年第9期595-599,共5页Cancer Research and Clinic

摘　　要：目的：检验欧洲癌症治疗与研究组织（EORTC）QLQ-STO22量表在我国胃癌患者中的有效性、可靠性与可接受性。方法以2014年9月至2015年4月期间在中南大学湘雅医学院附属肿瘤医院接受治疗的128例胃癌患者作为调查对象，完成量表EORTC QLQ-STO22和EORTC QLQ-C30，并进行Zubrod-ECOG-WHO（ZPS）评分。对结果采用克伦巴赫系数α、Pearson相关检验进行统计学分析。并用ZPS评分来检测EORTC QLQ-STO22量表的效度，在标准化评分后，以P〈0.05表示差异具有统计学意义。结果克伦巴赫系数α为0.607-0.830，表明EORTC QLQ-STO22量表有较好的可靠性，多项加强分析表明量表具有很好的聚合效度和区分效度。EORTC QLQ-C30与EORTC QLQ-STO22量表中相同或相似的维度具有较好的相关性，相关性得分均大于0.400。按照ZPS评分高低将患者分为四组，随ZPS评分的升高，患者整体生命质量得分依次递减，而与症状相关的条目得分则递增，且组间差异有统计学意义（P〈0.05）。结论 EORTC QLQ-STO22量表在我国胃癌患者中显示出较高的信效度，可以用于评价我国胃癌患者的生命质量。Objective To test the effectiveness, reliability and acceptability of the European Organization for Research and Treatment of Cancer （EORTC） QLQ-STO22 scale in gastric cancer patients in China. Methods One hundred and twenty-eight cases were collected in the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University from September 2014 to April 2015. All the patients completed the EORTC QLQ-STO22 and EORTC QLQ-C30 scales and given the Zubrod-ECOG-WHO （ZPS） score. Karen Bach coefficient and Pearson correlation test were used for statistical analysis while using ZPS score to detect EORTC QLQ-STO22 in validity. After score was standardized, P〈0.05 represented the difference had statistical significance. Results The Karen Bach coefficient was 0.607-0.830, confirming that the EORTC QLQ-STO22 scale had good reliability. A number of enhanced analysis showed that the scale had good convergent validity and divergent validity. In the same or similar dimension, EORTC QLQ-C30 and EORTC QLQ-STO22 scales had good correlation and the correlation scores were higher than 0.400. The patients were divided into four groups according to ZPS score, with ZPS score increase, the overall quality of life scores were decreasing and entries associated with symptoms were increasing, showing difference between different groups（P〈0.05）. Conclusion The EORTC QLQ-STO22 scale shows high reliability and validity that can be used for assessing the quality of life of patients with advanced gastric cancer in China.

关 键 词：胃肿瘤 生命质量 EORTC QLQ-STO22量表 中国 

分 类 号：R735.2[医药卫生—肿瘤]