血必净注射液治疗对晚期肺癌合并肺部感染患者血清炎性因子水平的影响  

Influence of Xuebijing Injection for the serum inflammatory factors of patients with advanced pulmonary cancer combined with pulmonary infection

作　　者：郭玉梅[1] 李政霖[1] 祁恒旭[2] 张芸[1] 舒姣洁 

机构地区：[1]辽宁省大连市中心医院急诊ICU,辽宁大连116033 [2]辽宁省大连市中心医院神经内科,辽宁大连116033

出　　处：《中国医药导报》2016年第32期125-128,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81301721)

摘　　要：目的探究血必净注射液治疗对晚期肺癌合并肺部感染患者血清炎性因子水平的影响。方法选取2014年1月~2016年6月辽宁省大连市中心医院收治的78例晚期肺癌合并肺部感染患者作为研究对象,将其随机分为对照组（常规治疗）39例和观察组（常规治疗加血必净注射液）39例。比较两组患者治疗后肺部感染症状体征改善时间、治疗总有效率、治疗前后的血清抗炎与促炎因子水平等。结果观察组肺部感染症状体征（发热、咳嗽及肺部啰音）改善时间均短于对照组（均P〈0.05）。观察组总有效率明显高于对照组,其中轻中度、重度肺部感染患者的总有效率也均明显高于对照组,差异均有统计学意义（均P〈0.05）。治疗后3、10、14 d,观察组血清白细胞介素（IL）-2水平均显著高于对照组（均P〈0.05）,其他血清抗炎因子（IL-4、IL-10及IL-13）与促炎因子[IL-1β、IL-6、IL-8及肿瘤坏死因子α（TNF-α）]水平均显著低于对照组（均P〈0.05）。结论血必净注射液治疗晚期肺癌合并肺部感染患者效果较好,能明显改善血清炎性因子水平。Objective To investigate the influence of Xuebijing Injection for the serum inflammatory factors of patients with advanced pulmonary cancer combined with pulmonary infection. Methods Seventy-eight patients with advanced pulmonary cancer combined with pulmonary infection admitted to Dalian Central Hospital from January 2014 to June2016 were selected as the research objects, and they were randomly divided into 39 cases of control group（conventional treatment） and 39 cases of observation group（conventional treatment combined with Xuebijing Injection）, then the improved time of symptoms and signs of pulmonary infection, total effective rates after treatment, and the levels of serum anti-inflammatory and pro-inflammatory factors before and after treatment in the two groups were compared.Results The improved time of symptoms and signs of pulmonary infection（fever, cough and pulmonary rales） of observation group was all shorter than those of control group（P〈0.05）. The total effective rate of observation group was higher than that of control group, among which, the total effective rates of patients with mild-moderate and severe pulmonary infection were also higher than those of control group, the differences were all statistically significant（P〈0.05）. After treatment for 3, 10, 14 d, the levels of serum interleukin（IL）-2 in the observation group were all higher than those of control group（P〈0.05）, the levels of other serum anti-inflammatory factors（IL-4, IL-10 and IL-13） and pro-inflammatory factors [IL-1β, IL-6, IL-8 and tumor necrosis factor-α（TNF-α）] were all lower than those of control group（P〈0.05）. Conclusion Xuebijing Injection in the treatment of patients with advanced pulmonary cancer combined with pulmonary infection has a better effect, which can significantly improve the serum inflammatory factors.

关 键 词：血必净注射液 晚期肺癌 肺部感染 炎性因子 

分 类 号：R734.2[医药卫生—肿瘤]