肿瘤相关性炎症与结肠癌  

Role of cancer-related inflammation in colon cancer

作　　者：崔曼莉[1] 张明鑫[1] 张超[1] 王景杰[1] 

机构地区：[1]第四军医大学唐都医院消化内科,陕西省西安市710038

出　　处：《世界华人消化杂志》2016年第32期4343-4353,共11页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81302055~~

摘　　要：慢性炎症是结肠癌发病的重要机制之一,而肿瘤相关性炎症(cancer related inflammation,C R I)在肿瘤发生发展中的重要作用是近年来研究的热点问题.因此,明确CRI在结肠癌中的作用及调控具有重要意义.转录因子、细胞因子、趋化因子、环氧合酶-2以及微小RNA等是CRI中重要的信号通路.本文仅就上述信号通路在结肠癌中的研究进展进行述评.Chronic inflammation is one of the important mechanisms for the development of colon cancer,and the role of cancer-related inflammation（CRI） in tumor development is a hot research topic in recent years.Therefore,it is very important to clarify the effect and regulation of CRI in colon cancer.Accumulating evidence indicates that transcription factors,cytokines,chemokines,cyclooxygenase-2 and microR NAs play key roles in CRI.This review focuses on the research progress about these molecules in colon cancer.

关 键 词：肿瘤相关性炎症 结肠癌 调控 

分 类 号：R735.35[医药卫生—肿瘤]