一种合成二氢黄酮醇衍生物的简易方法  

A Facile Method to Prepare Dihydroflavonol Derivatives

作　　者：周宗宝[1] 王红[1] 陶凯奇 叶晓川[1] 胡春玲[1] 

机构地区：[1]湖北中医药大学药学院中药化学与中药资源省级重点实验室,武汉430065

出　　处：《有机化学》2016年第11期2752-2756,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.31370378)资助项目~~

摘　　要：以2'-羟基查尔酮衍生物为原料,在低温条件下,以四氢呋喃为溶剂,在H_2O_2/(C_2H_5)_2NH体系中,高收率地实现一系列二氢黄酮醇类衍生物的合成.考查了反应温度、反应溶剂、碱添加剂的种类和比例以及氧化剂的种类和比例对该反应的影响,确定了最优反应条件.此合成方法具有操作简单、条件温和及后处理方便等特点.此外,所合成产物的结构经核磁共振谱表征确证.A series of dihydroflavonol derivatives were synthesized by the reaction of 2＇-hydroxyl chalcone derivatives with H2O2/（CH3CH2）2NH system in anhydrous tetrahydrofuran under low temperature. The influences of reaction temperature, re- action solvents, the kinds and proportion of alkaline additive and oxidants on this reaction were investigated, and the optimal reaction conditions were determined. This method has the advantages of simple operation, mild conditions and convenient post-treatment. Besides, all synthetic products were fully characterized by NMR spectra.

关 键 词：2’-羟基查尔酮衍生物 二氢黄酮醇类衍生物 简易的方法 

分 类 号：O621.3[理学—有机化学]