光动力疗法的抗肿瘤机制及光敏剂的研究进展  

Research advances in action mechanisms of photodynamic therapy and photosensitizer

作　　者：史澍睿 王悦[1] 万国运 王银松[2] 张连云[1] 张娟[1] 

机构地区：[1]天津医科大学附属口腔医院口腔修复科,300070 [2]天津医科大学药学院,300070

出　　处：《国际生物医学工程杂志》2016年第5期303-308,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金（81572655,81573005）

摘　　要：光动力疗法（PDT）是利用光动力效应对疾病进行诊断与治疗的一种非侵袭性技术,已被用于临床头颈部、乳腺、肺、前列腺及皮肤等部位肿瘤的治疗.与传统治疗方法相比,PDT具有创伤小、毒性低、选择性好、适用范围广及不易产生耐药等优势,因而受到肿瘤治疗领域的广泛关注.PDT的抗肿瘤机制复杂,光敏剂是发挥其光动力学效应的关键因素之一,提高光敏剂的靶向输送和携氧能力是改善光动力疗效的重要途径.对PDT的抗肿瘤机制及光敏剂的研究进展进行综述.Photodynamic therapy （PDT） is a noninvasive technique for diagnosis and therapy of diseases by using the photodynamic effects.Clinically,PDT has been used in the treatments of various tumors in head and neck,pancreas,lung,prostate and skin.Compared to the traditional treatments of tumors,PDT exhibits many advantages such as less damage,low toxicity,good selectivity,wide applicability and less drug resistance,which draw more attention in the field of tumor therapy.The action mechanisms of PDT against tumors are very complicated and photosensitizer is one of the key factors that influence the photodynamic effects of PDT.To enhance the tumor-targeted delivery of photosensitizer and improve their oxygen-carrying ability are believed as the important ways to increase the photodynamic effects.In this paper,review is given on the research advances in action mechanisms of photodynamic therapy and photosensitizer in recent years.

关 键 词：光动力疗法 光敏剂 作用机制 

分 类 号：R730.5[医药卫生—肿瘤]