HP感染及口服非甾体抗炎药与消化性溃疡并发出血之间的关系研究  

Study on the relationship between HP infection and oral non steroidal anti infl ammatory drugs and peptic ulcer complicated with hemorrhage

作　　者：尹丹萍[1] 张玉强[1] 巩霞[1] 

机构地区：[1]山东省济南军区总医院疾病预防控制科,山东济南250031

出　　处：《临床医药文献电子杂志》2016年第34期6710-6711,共2页Electronic Journal of Clinical Medical Literature

基　　金：2015年度济南军区总医院院长基金(2015QN02)

摘　　要：目的 探讨幽门螺杆菌（HP）感染及非甾体抗炎药与消化性溃疡并发出血的相关性.方法 选取2014年5月~2016年3月收治的消化性溃疡患者160例作为研究对象,回顾性分析患者的临床资料,将其随机分成出血组68例与未出血组92例,将其危险因素进行单因素及多因素分析.结果 单因素分析显示,出血组患者年龄≥60岁、存在消化道出血史、心脑血管疾病及服用非甾体抗炎药的占比显著高于未出血组患者,差异有统计学意义（P〈0.05）;进行多因素logistic回顾分析,结果 发现年龄≥60岁、存在消化道溃疡史、心脑血管疾病、消化道出血史、单纯的Hp感染、单纯口服非甾体抗炎药与Hp感染配合服用非甾体抗炎药都为消化性溃疡并发出血的高危因素（P〈0.05）.结论 单纯的Hp感染并没有起到增加消化性溃疡并发出血的危险性,但在患者年龄≥60岁、有消化道出血史、口服非甾体抗炎药、存在消化性溃疡史、心脑血管疾病史等多种因素的共同作用下,其危险性将大大增加.Objective To investigate the relationship between Helicobacter pylori （HP） infection and non steroidal anti inflammatory drugs and peptic ulcer complicated with hemorrhage. Methods From May 2014 to March 2016 were 160 cases of peptic ulcer patients as the research object, a retrospective analysis of clinical data of patients, were randomly divided in.to 68 cases of hemorrhage group and non bleeding group＇in 92 cases, the risk factors of single factor and multi factor analysis. Results Univariate analysis showed that patients with age more than 60 years old, had gastrointestinal bleeding history, cardiovascular disease and non steroidal anti-inflammatory drugs accounted for significantly higher than non hemorrhage group, the difference was statistically significant （P〈0.05）; multi factor retrospective analysis of logistic, the 60 years of age or older, digestive tract history of ulcer, cardiovascular and cerebrovasenlar diseases, digestive tract bleeding history, simple Hp infection, simple oral non steroidal anti-inflammatory drugs and Hp infection with non steroidal anti-inflammatory drugs are risk factors for peptic ulcer hemorrhage （P〈0.05）. Conclusion Hp infection alone does not serve to increase the risk of peptic ulcer bleeding, but the patient＇s age is greater than or equal to 60 years of age, have a history of gastrointestinal bleeding, oral non-steroidal anti-inflammatory drugs, there is a history of peptic ulcer, the joint action of various factors cardio-cerebral vascular disease history, the risk will be greatly increased.

关 键 词：幽门螺杆菌感染 非甾体抗炎药 消化性溃疡 相关性 

分 类 号：R573[医药卫生—消化系统]