幼少女生殖系统恶性肿瘤临床病理分析  

Clinical and pathological analysis of malignant tumors of the reproductive system of young girls

作　　者：赵群[1] 张琪[1] 罗亚[1] 康海利[1] 段微[1] 吴玉梅[1] 

机构地区：[1]首都医科大学附属北京妇产医院妇瘤科,100006

出　　处：《北京医学》2016年第11期1174-1177,共4页Beijing Medical Journal

摘　　要：目的分析幼少女生殖系统恶性肿瘤的临床病理特点及诊治方法。方法回顾性收集2001年1月至2016年5月于首都医科大学附属北京妇产医院妇瘤科诊治的幼年及少年女性生殖系统恶性肿瘤患者病例资料。结果本组12例,年龄10个月至14岁,<5岁者占75%,≥5岁者占25%。病理以卵巢或阴道卵黄囊瘤(6例)和阴道横纹肌肉瘤(4例)为主,其余包括性腺母细胞瘤和幼年型颗粒细胞瘤各1例。生殖细胞肿瘤共占58.3%。患儿主要临床症状为阴道出血、排液,发现外阴肿物及盆腔肿物。治疗以肿物局部切除和化疗为主。卵黄囊瘤及幼年型颗粒细胞瘤患儿预后较好。横纹肌肉瘤预后极差,对化疗不敏感。结论幼少女生殖系统恶性肿瘤发生率低,应及早发现,手术切除肿瘤并辅助规范化化疗。Objective To analyze the clinical and pathologic characteristics and treatment methods for malignant tumors in the reproductive system of young girls. Methods Twelve cases of young girls with genital malignant tumor who were treated in our hospital from January 2001 to May 2016 were retrospectively analyzed. Results The age of patients ranged from 10 months to 14 years old. 75% were less than 5 years old, 25% were older than 5 years old. The major pathologies were vaginal or ovarian yolk sac tumor（6 cases） and vaginal rhabdomyosarcoma（4 cases）. Other pathologies included germ cell tumor（1 case） and juvenile granulosa cell tumor（1 case）. Germ cell carcinoma accounted for 58.3%. The main clinical symptoms were vaginal bleeding, vaginal discharge, finding vulva tumor and pelvic tumor. Treatments included tumor excision and chemotherapy. The outcomes of yolk sac tumor and juvenile granulosa cell tumor were much better than rhabdomyosarcoma which was not sensitive to chemotherapy. Conclusion The incidence of genital malignant tumor in young girls is very low. We should detect the genital malignant tumor in young girls as early as possible, excise the tumor and initiate adjuvant chemotherapy.

关 键 词：幼少女 生殖系统 恶性肿瘤 

分 类 号：R737.3[医药卫生—肿瘤]