肺鳞癌和腺癌中E-钙黏附素和基质金属蛋白酶-9的病理意义  

Expression and clinical significance of E-cadherin and MMP-9 in lung squamous carcinoma and adenocarcinoma

作　　者：刘云云 王保军 齐战[2] 

机构地区：[1]河北省临西县第二人民医院内科,054901 [2]河北医科大学第四医院胸外科

出　　处：《河北医药》2016年第24期3690-3694,共5页Hebei Medical Journal

摘　　要：目的检测肺癌组织中E-钙黏附素(E-cadherin)和基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)的表达,并对两者与临床病理特征的关系进行了研究。方法应用免疫组织化学方法,对138例肺鳞癌和肺腺癌以及对应的癌旁正常肺组织中E-cadherin和MMP-9蛋白的表达情况进行了检测。结果肺癌组织中E-cadherin的阳性表达率为28.99%(40/138),正常肺组织为66.67%(92/138),两者比较,差异有统计学意义(P<0.05);在肺癌组织中,MMP-9的阳性表达率为59.42%(82/138),正常肺组织为29.71%(41/138),两者比较,差异有统计学意义(P<0.05);E-cadherin和MMP-9的表达水平均与肺癌的分化程度、TNM分期、淋巴结转移及术后生存时间有明显相关(P<0.05);两者的表达与病理类型、性别、年龄、吸烟史无关(P>0.05);E-cadherin蛋白的表达与MMP-9蛋白的表达呈负相关(P<0.05)。结论 E-cadherin低表达与MMP-9高表达是肺癌侵袭转移的重要生物学指标。Objective To observe the expressions of E-cadherin and matrix metalloproteinase-9（ MMP-9） in lung cancer tissues,and to analyze the correlation between their expressions and clinicopathological characteristics of lung cancer.Methods The expression levels of E-cadherin and MMP-9 proteins were detected by immunohistochemistry（ SP） in 138 cases of lung squamous carcinoma and lung adenocarcinoma as well as adjacent normal lung tissues. Results The positive expression rate of E-cadherin in lung cancer tissues was 28. 99%（ 40 /138）,however,which was 66. 67%（ 92 /138） in normal lung tissues,there was a significant difference between them（ P〈 0. 05）. The positive expression rate of MMP-9 in lung cancer tissues was 59. 42%（ 82 /138）,however,which was 29. 71%（ 41 /138） in normal lung tissues,there was a significant difference between them（ P〈 0. 05）. The expression levels of E-cadherin and MMP-9 were closely correlated to the differentiation degree,TNM staging of lung cancer,lymph node metastasis of lung cancer and patient＇s survival time after surgery（ P〈 0. 05）,however,the expression levels of E-cadherin and MMP-9 were not related with pathological type of lung cancer,patient＇s sex and age,smoking history（ P〉 0. 05）. Moreover the expression of E-cadherin was negatively correlated to that of MMP-9（ P〈0. 05）. Conclusion The low expression of E-cadherin and high expression of MMP-9 may be important biological indexes of invasion and metastasis of lung cancer.

关 键 词：肺癌 E-CADHERIN MMP-9 侵袭转移 

分 类 号：R734.2[医药卫生—肿瘤]