肿瘤脂质代谢关键酶的研究进展  

Progress in the key enzymes in tumor lipid metabolism

作　　者：袁龙[1] 赵盼[1] 朱文华[1] 管静芝[1] 

机构地区：[1]解放军第309医院肿瘤科,北京100091

出　　处：《肿瘤研究与临床》2016年第11期789-792,共4页Cancer Research and Clinic

基　　金：国家自然科学基金（81170329）

摘　　要：脂质代谢对肿瘤细胞的发生、发展有着重要的影响。正常细胞通过循环系统中的脂质来提供能量，而肿瘤通过自身的从头合成来提供能量，这种异常的脂质代谢不仅为其快速增殖提供能量，而且相关的脂质是参与肿瘤信号通路的重要分子。越来越多的研究发现脂质代谢与肿瘤细胞的发生、发展关系密切，其中脂质代谢过程中的一些关键酶如脂肪合成酶（FASN）、硬脂酰辅酶A脱氢酶1（SCD1）成为研究热点。这些关键酶在肿瘤组织中的表达较正常组织升高，有望作为肿瘤诊断及治疗的新靶点。文章将对脂质代谢与肿瘤发生、发展的关系进行综述。Lipid metabolism plays an important role in the occurrence and development of tumor cells. The normal cells provide energy through lipids in the circulation system, while tumor cells provide energy through their own de novo synthesis. This abnormal lipid metabolism not only supplies energy for tumor cells to rapidly proliferate, but also related lipids are involved in the important molecular signal pathways of tumor. Increasing studies have found that there is a close relationship between the lipid metabolism and the development of tumor cells. Some key enzymes in the process of lipid metabolism, such as fatty acid synthase （FASN） and stearoyl-coenzyme A desaturase 1 （SCD1）, have become the research hotspot. The expressions of these key enzymes are significantly higher in tumor tissues than those in normal tissue, which indicates that these enzymes are expected to become new targets for tumor diagnosis and therapy. This review mainly describes the relationship between lipid metabolism and tumor development.

关 键 词：脂质代谢 脂肪合成酶 硬脂酰辅酶A脱氢酶1 

分 类 号：R730.2[医药卫生—肿瘤]