结肠癌组织中Bmi-1和p53的表达及意义  

Expressions of Bmi-1 and p53 and significance in colon cancer

作　　者：贺亚敏[1] 高丽丽[1] 李惠[1] 钱晓萍[2] 

机构地区：[1]南京中医药大学附属医院,江苏省中医院病理科,江苏南京210029 [2]南京中医药大学中西医结合鼓楼临床医学院肿瘤中心,江苏南京210008

出　　处：《现代肿瘤医学》2017年第2期269-272,共4页Journal of Modern Oncology

基　　金：江苏省自然科学基金(编号:BK20161107)

摘　　要：目的:探析结肠癌组织中Bmi-1和p53的表达情况及意义。方法:采用免疫组织化学SP法对60例结肠癌及其相应癌旁组织中Bmi-1和p53的蛋白表达情况进行检测。结果:结肠癌组织中Bmi-1阳性表达34例(阳性率为56.7%),相应癌旁结肠组织中阳性表达2例(3.33%),结肠癌组织中p53阳性表达44例(阳性率为73.3%),相应癌旁组织中无阳性表达(0%),结肠癌与正常组织中Bmi-1和p53表达率差异具有统计学意义(P<0.05);Bmi-1和p53的表达与患者的一般资料如年龄、性别和浸润深度方面关联不大(P>0.05),而与分化程度、有无淋巴结转移(P<0.05)及Duke's分期(P<0.01)方面关联明显。同时,Bmi-1和p53的表达呈显著正相关(r=0.461,P<0.01)。结论:Bmi-1和p53的表达情况可作为评估结肠癌预后的有效指标,Bmi-1和p53可能成为预测结肠癌高度转移的新分子标志物。Objective：To investigate expressions and significance of Bmi-1 and p53 in colon cancer.Methods：Expression of Bmi-1 and p53 were detected in 60 cases of tumor tissues and tumor-adjacent normal tissues by the immunohistochemical SP method.Results：The positive expression of Bmi-1 in colon cancer were 34 cases（ the positive rate was 56.7%） and 2 cases in cancer adjacent normal tissues（ the positive rate was 3.33%）.The positive expression of p53 in colon cancer were 44 cases and the positive rate was 73.3%.The positive expression of p53 in cancer adjacent normal tissues was 0%.The differential expressions of Bmi-1 and p53 in colon cancer and normal tissues had significant difference（ P〈0.05）.Over-expression of Bmi-1 and p53 had no relation with age,gender and tumor depth（ P〉0.05）,but was significantly related to tumor differentiation,lymph node metastasis,and Duke＇s staging（ P〈0.05,P〈 0.01）.Bmi-1 and p53 expression was positively correlated（ r = 0.461,P〈0.01）.Conclusion：The expression of Bmi-1 and p53 can be used as an effective index to evaluate the prognosis of colon cancer.Bmi-1 and p53 may be new molecular markers for predicting the metastasis of colon cancer.

关 键 词：肠癌 BMI-1 P53 表达 

分 类 号：R735.35[医药卫生—肿瘤]