c-myc基因和p53蛋白在喉癌切缘组织的表达与局部复发的相关性研究  

Correlation between the expressions of c-myc gene and p53 protein in laryngeal cancer edge tissues and local recurrence

作　　者：余晓虹 罗鸿[1] 朱晓玲[1] 李鹤[1] 刘开瑞[1] 

机构地区：[1]襄阳市中心医院北区耳鼻喉科,湖北襄阳441003

出　　处：《安徽医药》2016年第10期1919-1922,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的通过检测c-myc基因(c-myc)和p53蛋白在喉癌切缘组织的表达,探讨其与术后局部复发的相关性。方法选择接受治疗的喉癌患者201例,将患者按复发与否分成复发组和非复发组,校正一般资料后,采用免疫组化法对两组患者喉癌组织和切缘组织中c-myc和p53蛋白的表达进行比较。结果 (1)在喉癌组织中,c-myc蛋白在复发组和未复发组表达的阳性率分别为54.5%和50.0%,差异无统计学意义(P>0.05);p53蛋白在复发组和未复发组表达的阳性率分别为84.8%和91.1%,差异无统计学意义(P>0.05);(2)在切缘组织中,c-myc蛋白在复发组和未复发组表达的阳性率分别为66.7%和20.8%,差异有统计学意义(P<0.05);p53蛋白在复发组和未复发组表达的阳性率分别为84.8%和81.0%,差异无统计学意义(P>0.05);(3)边缘黏膜异型增生型发生率在复发组和未复发组分别是63.6%和45.8%,差异无统计学意义(P>0.05)。结论切缘组织中c-myc蛋白的表达与喉癌术后局部复发具有明显相关性,或可作为局部复发状况的预测指标。Objective To explore the correlation of c-myc gene and p53 protein with local recurrence in laryngeal cancer edge tissues. Methods Totally 201 patients with laryngeal cancer treated in Xiangyang Central Hospital were assigned into 2 groups, recurrence group and non-recurrence group. The expressions of c-myc gene and p53 protein in laryngeal cancer edge tissues were analyzed after correcting clinical data between two groups. Results In laryngeal cancer tissues, the positive rates of the expression of e-myc gene in group A and group B were 54.5% and 50.0% respectively,and they were not statistically different（P 〉0.05） ;the expressions of p53 protein in group A and group B were 84.8% and 91.1% respectively, and they were not statistically different either（ P 〉 0.05 ）. In edge tissues,the positive rates of the expression of c-myc gene in group A and group B were 66.7% and 20.8% respectively, and they were statistically different （P 〈0.05 ） ;the expression of p53 protein in group A and group B were 84.8% and 81.0% respectively,and they were not statistically different （ P 〉 0.05 ）. The incidences of mucosa dysplasia on edge tissues in group A and group B were 63.6% and 45.8% respectively, and they were not statistically different （ P 〉 0.05 ）. Conclusions The expression of c-mye gene in edge tissues has obvious correlation with postoperative local recurrence of laryngeal cancer, which can become a forecast indicator of lo- cal recurrence.

关 键 词：喉癌 局部复发 C-MYC p53 

分 类 号：R739.65[医药卫生—肿瘤]