MMP-2的表达及微血管密度与乳腺癌淋巴结转移的关系  

MMP-2 expression,microvessel density and metastasis of lymph node in breast cancer

作　　者：任俊玲 王亚兵[2] 陈斌[2] 

机构地区：[1]芜湖市第一人民医院普外科,安徽芜湖241000 [2]皖南医学院第一附属医院弋矶山医院甲乳外科,安徽芜湖241001

出　　处：《皖南医学院学报》2016年第6期537-539,共3页Journal of Wannan Medical College

基　　金：安徽省卫生厅医学科研项目(09B132)

摘　　要：目的:探讨乳腺癌组织中基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)的表达及微血管密度(microvessel density,MVD)与乳腺癌生物学特性的相关性。方法:采用免疫组织化学方法检测62例乳腺癌组织中MMP-2和MVD(CD34)表达。结果:淋转组MMP-2的阳性表达率(74%)、表达强度及MVD值(48.05±13.49)明显高于非淋转组(P<0.05);MVD值在MMP-2不同表达中存在差异;MMP-2的表达和MVD的含量在不同乳腺癌TNM分期中存在差异。结论:MMP-2可通过促进降解细胞外基质、促进乳腺癌新生血管形成而促进乳腺癌的进展,MMP-2及MVD在乳腺癌发展及转移中可能发挥重要作用。Objective：To investigate the relationship between matrix metalloproteinase-2（ MMP-2） expression,microvessel density（ MVD） and the biologi-cal property in breast carcinoma.Methods：Immunohistochemistry was used to detect MMP-2 expression and MVD in the breast cancer tissues obtained from 62 patients.Results：Patients with lymph node metastasis had significantly higher positive rate of MMP-2（74%） and MVD（48.05±13.49） than those with-out lymph node involvement（P〈0.05）.MVD value varied to a certain extent in diverse MMP-2 expression,and MMP-2 expression and MVD content were distinct in patients with diverse TNM staging for breast cancer .Conclusion：MMP-2 may promote the progression of breast cancer through hastening the degradation of extracellular matrix and accelerating neovascularization ,suggesting that MMP-2 and MVD play critical part in the development and lymph node metastasis of breast carcinoma.

关 键 词：乳腺癌 基质金属蛋白酶-2 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤]