阿莫西林克拉维酸钾对急诊肠梗阻手术减张缝合患者术后感染及炎症指标的影响  

Influence of amoxicillin and clavulanate potassium on postoperative infection and inflammatory indexes in emergency intestinal obstruction operation by relaxation suture

作　　者：于永洋[1] 黄耘[2] 刘昭晖[1] 张福星[1] 

机构地区：[1]厦门大学附属第一医院普外科,福建厦门361003 [2]厦门大学附属第一医院血液科,福建厦门361003

出　　处：《中国生化药物杂志》2016年第11期53-55,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的研究阿莫西林克拉维酸钾对急诊肠梗阻手术减张缝合患者术后感染相关及炎症指标的影响。方法将2014年4月-2016年4月期间厦门大学附属第一医院普外科的80例急诊肠梗阻手术减张缝合患者随机分为对照组和观察组,各40例,对照组进行常规治疗,观察组在对照组基础上加用阿莫西林克拉维酸钾。比较2组术后感染发生率、治疗前后的炎症相关指标。结果观察组术后感染率为5.00%,明显低于对照组的17.50%,差异有统计学意义（P〈0.05）。治疗前,2组患者血清炎症相关指标比较,差异无统计学意义;治疗后1、2、5 d,血清抗炎指标白细胞介素-4（interleukin-4,IL-4）、IL-10、IL-13和促炎指标肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、IL-6,均低于对照组;促炎指标IL-2,均高于对照组,差异有统计学意义（P〈0.05）。结论阿莫西林克拉维酸钾可降低急诊肠梗阻手术减张缝合患者术后感染发生,同时对相关炎症指标的控制效果较好。Objective To study the influence situation of amoxicillin and clavulanate potassium for the postoperative infection and inflammatory indexes of patients with emergency intestinal obstruction operation by relaxation suture. Methods 80 patients with emergency intestinal obstruction operation by relaxation suture in department of general gurgery of our hospital from April 2014 to April 2016 were randomly divided into control group and observation group with 40 cases in each group,the control group were treated with routine treatment,the observation group were treated with amoxicillin and clavulanate potassium on the treatment of control group,then the postoperative infection rates,inflammatory related indexes before and after the treatment of two groups were compared. Results The postoperative infection rate of observation group was 5. 00%,and it was obviously lower than the17. 50% of control group,the difference was significant（ P〈0. 05）; the serum inflammatory related indexes of two groups before the treatment were compared,the differences were not significant; the serum anti-inflammatory indexes interleukin-4（ IL-4）,IL-10,IL-13 and pro-inflammatory indexes tumor necrosis factor-α（ TNF-α）,IL-6 at 1st,2nd and 5th day after the treatment were all lower than those of control group,the pro-inflammatory index IL-2 were higher than those of control group,the differences were all significant（ P〈0. 05）. Conclusion The amoxicillin and clavulanate potassium can reduce the postoperative infection of patients with emergency intestinal obstruction operation by relaxation suture,and its control role for the related inflammatory indexes is better,so its application value is higher and is worthy of clinical promotion.

关 键 词：阿莫西林克拉维酸钾 急诊肠梗阻手术 减张缝合 感染相关指标 

分 类 号：R574.2[医药卫生—消化系统] R63[医药卫生—内科学]