放疗联合介入治疗对中晚期宫颈癌患者血管内皮生长因子水平的影响  

Effect of radiotherapy combined with interventional therapy on vascular endothelial growth factor in patients with advanced cervical cancer

作　　者：刘珍[1] 苏小岩[1] 胡艳[1] 许海[2] 

机构地区：[1]湖北省荆州市第一人民医院肿瘤科,湖北荆州434000 [2]湖北中医药大学黄家湖医院妇科,湖北武汉430060

出　　处：《中国生化药物杂志》2016年第11期112-114,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：中国博士后科学基金(2013M542498)

摘　　要：目的探讨放疗联合介入治疗对中晚期宫颈癌患者血管内皮生长因子（VEGF）水平的影响。方法选取2009年1月-2014年2月湖北省荆州市第一人民医院收治的宫颈癌患者62例,完全随机分为A、B两组,A组患者采用放疗,B组患者采用放疗联合介入治疗。采用酶联免疫法来测定治疗后2组患者血管内皮生长因子水平。结果 A组介入治疗的患者血管内皮生长因子的水平为（241.77±85.86）μg/L,明显高于B组放射治疗的患者的数值（124.66±65.86）μg/L。血管内皮生长因子水平与患者宫颈癌的恶化程度,肿瘤分期及淋巴结转移有关（P〈0.05）,而与患者年龄、瘤体大小无关。血管内皮生长因子水平与治疗后患者临床疗效有关（P〈0.05）。结论血管内皮生长因子的水平的高低与宫颈癌恶化程度、肿瘤的分期、淋巴结转移情况以及介入治疗后的疗效有密切的关系。Objective To investigate the effect of radiotherapy combined with interventional therapy on the changes of vascular endothelial growth factor（ VEGF） in patients with advanced cervical cancer. Methods 62 cases of cervical cancer collected in the first people＇s hospital of jingzhou city during January 2009 to February 2014 were randomly divided into two groups. The patients in group A were treated with radiotherapy,and the patients in group B were treated with radiotherapy combined with interventional therapy. The level of vascular endothelial growth factor in two groups after treatment was measured by enzyme-linked immunoassay. Results The level of vascular endothelial growth factor of group A was（ 241. 77 ± 85. 86） μg/L,significantly higher than（ 124. 66 ± 65. 86） μg/L of group B. The level of vascular endothelial growth factor was related with cervical deterioration degree,tumor stage and lymph nodes metastasis（ P〈0. 05）,not with the patient＇s age,and the size of the tumors. The level of vascular endothelial growth can reflect the clinical efficacy of patients after therapy（ P〈0. 05）. Conclusion Vascular endothelial growth factor level has a close relationship with the degree of deterioration of cervical cancer,tumor staging,lymph node metastasis and the curative effect after the interventional therapy.

关 键 词：血管内皮生长因子 中晚期宫颈癌 介入治疗 放射治疗 

分 类 号：R737.33[医药卫生—肿瘤]