食管癌患者血清VEGF、TNF-α和IL-6表达与预后的相关性  

Correlation of serum VEGF,TNF-α,IL-6 and prognosis of patients with esophageal cancer

作　　者：胡金华 张耀晴 朱斌 

机构地区：[1]京山县人民医院普外2科,湖北京山431899

出　　处：《现代肿瘤医学》2017年第1期63-66,共4页Journal of Modern Oncology

摘　　要：目的:探讨食管癌患者血清VEGF、TNF-α和IL-6的浓度变化与食管癌分期及转移的相关性。方法:采用双抗体夹心酶联免疫吸附法(ELISA)测定128例食管癌患者(食管癌组)和84例食管平滑肌瘤患者(食管平滑肌瘤组)的血清VEGF、TNF-α和IL-6浓度,并与80例健康成年人(对照组)比较。结果:食管癌组血清VEGF、TNF-α和IL-6水平均高于食管平滑肌瘤组和对照组(P<0.01)。食管癌患者Ⅳ期组>Ⅲ期组>Ⅰ、Ⅱ期组(P<0.01)。伴有淋巴转移的食管癌患者显著高于无淋巴转移的患者(P<0.01)。结论:外周血VEGF、TNF-α和IL-6水平与食管癌的侵袭、转移密切相关,检测其表达水平对判断食管癌患者病情进展及预后有重要意义。Objective： To investigate the correlation of serum TNF- α,IL- 6,VEGF and patients with differentiated esophageal cancer invasion and metastasis. Methods： Serum levels of TNF- α,IL- 6 and VEGF were quantified by ELISA on 128 cases of differentiated esophageal cancer（ esophageal cancer group）,84 cases of esophageal leiomyoma（ esophageal leiomyoma group）,and 80 healthy people（ control group）. Results： The serum concentrations of TNF- α,IL- 6 and VEGF in esophageal cancer were higher than leiomyoma of esophagus group and control group（ P〈0. 01）. Concentrations of TNF- α,IL- 6 and VEGF were higher in stage Ⅳ〉 stage Ⅲ〉 stage Ⅰ and Ⅱ. Comparing with no lymphatic metastasis group,with lymphatic metastasis group was higher has statistical significance（ P〈0. 01）. Conclusion： The serum levels of TNF- α,IL- 6 and VEGF have positive correlation to the invasion and metastasis of differentiated esophageal cancer. There is of great significance of TNF- α,IL- 6 and VEGF serum levels for estimating the progression and prognosis of patients with esophageal cancer.

关 键 词：食管癌 TNF-Α IL-6 VEGF 肿瘤分期 淋巴转移 

分 类 号：R735.1[医药卫生—肿瘤]